Reaction to study proposing new mechanism to explain asthma attacks
An international team of researchers, with Spanish participation, has proposed in the journal Science a new mechanism to explain asthma attacks more fully. According to their hypothesis, the mechanical forces that occur during these episodes cause cells to accumulate in excess, leading to a process of elimination called "cell extrusion". As a result, the tissue is damaged, loses its barrier function and increases the risk of successive attacks. Inhibitors of this mechanism improved damage and inflammation in laboratory mice.
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