Paresh Malhotra

Paresh Malhotra

Paresh Malhotra
Position

Head of the Division of Neurology in the Department of Brain Science, Imperial College London

A new blood test could help with the early detection of Alzheimer's, according to a study

A team from the United States analyzed blood levels of three biomarkers associated with Alzheimer’s disease in 1,350 people without dementia, with an average age of 61. Higher levels were associated with poorer cognitive performance five years later, leading the authors to state that the findings “demonstrate the potential for early detection of Alzheimer’s disease in middle-aged adults through blood tests.” In a related commentary, two experts who did not participate in the study state that, in young populations without cognitive impairment, these tests “may generate a higher rate of false positives” and caution that “they are not suitable for mass, non-selective screening for Alzheimer’s disease pathology in cognitively healthy populations or in the general community.” The study is published in The Lancet.

 

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Reactions to the approval of lecanemab for the treatment of Alzheimer's patients in the US

The drug lecanemab (Leqembi™) has received full approval as a treatment for early Alzheimer's disease by the US Food and Drug Administration (FDA), after confirming its clinical benefit in a trial involving 1,795 patients. The FDA highlights the warning that in rare cases it can cause serious and potentially life-threatening side effects.

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