Catholic University of Murcia (UCAM)
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Professor of Biochemistry, Vice-Chancellor for Research
Neurologist at Santa Lucía General Hospital in Cartagena, associate professor of Pharmacology at the Catholic University of Murcia (UCAM), researcher in neuropsychiatry at the Murcian Institute for Bio-Health Research (IMIB)
Single and repeated intravenous ketamine infusions are effective in reducing suicidal and depressive symptoms in patients with an acute episode of major depression. These are the main conclusions of a systematic review and meta-analysis published today in the journal JAMA Psychiatry, which also notes that long-term outcomes are not well established.
Individualised dosing of a synthetic inhalable formulation of mebufotenine, a psychedelic substance, led to improvements in depressive symptoms compared with placebo and was well tolerated. These are the results of a phase 2 clinical trial published in the journal JAMA Psychiatry, which includes Spanish participation. According to the authors, this supports its potential as a novel, fast-acting treatment for treatment-resistant depression.
An oral formulation of risperidone could be administered weekly instead of daily to treat patients with schizophrenia with the same efficacy, according to a phase III clinical trial published in The Lancet Psychiatry. The study included 83 patients in the United States.