Reacción a "Only 5% of therapies studied in animals are ever approved for use in humans"

In the field of liver disease research, we are aware of the intrinsic limitations of animal models. However, we believe that they remain essential for understanding both the mechanisms of action of new drugs, as well as for better understanding the pathophysiology of diseases affecting the liver. 

Regarding this article, I believe that we should take its conclusions with caution as the type of analysis performed is based on an evaluation of already published review articles (it is not based on directly analysing and comparing original preclinical and clinical articles) and, therefore, there may be some bias derived from the conclusions or opinions of the authors of these reviews. 

Translational researchers must continue to work to improve and optimise the animal models used in biomedical research, always following the highest ethical standards in the treatment and care of animals. In the case of the study of liver disease, we must continue to develop models that better mimic the disease in humans, including adult models, that include both sexes, and that mimic the disease both cellularly and pathophysiologically to that of humans.