Clínic Hospital

Cancer patients receiving a type of immunotherapy known as Immune Checkpoint Inhibitor (ICI) have a higher risk of serious adverse events, such as aortic aneurysm rupture, interstitial lung disease, myositis and liver failure, according to a study published in PNAS. "Establishing formal contraindications for ICI users seems warranted," concludes the analysis, based on more than 290,000 cases from pharmacovigilance databases of the US Food and Drug Administration and the World Health Organisation.

The combination of the antiretrovirals bictegravir and lenacapavir in a single tablet allows HIV treatment —previously based on multiple daily medications— to be simplified, according to the results of a new phase 3 clinical trial published in The Lancet. The trial, which included over 550 people living with HIV from 15 countries with a median age of 60, showed that the new treatment was just as effective at maintaining viral suppression as multi-drug regimens. Most participants were taking between two and eleven tablets daily, and around 40 % were on antiretrovirals more than once a day. The results were presented at the 2026 Conference on Retroviruses and Opportunistic Infections (CROI) in Denver, USA.

The study of psychedelic drugs in pharmacological treatments had its eureka moment with chemist Albert Hofmann's famous bike ride under the influence of LSD in 1938 and then developed over decades, but with Richard Nixon it was shelved. In recent years, it has resurfaced in hospitals and laboratories around the world. Last week, the Congress of Deputies hosted a conference on these substances. We explain what they are, what they are used for, the current state of research, and their risks, with the help of expert sources.

A team in China has studied the ability of a test to detect the human papillomavirus (HPV)—responsible for the vast majority of cervical cancers—in menstrual blood from more than 3,000 women. The results indicate that the test is comparable to current screening performed in medical offices. According to the researchers, “Using menstrual blood for HPV testing is practical and non-invasive, allowing women to collect samples at home and thus potentially offering a practical way to expand access to screening.” The study is published in The BMJ. 

A study published in The BMJ suggests that the incidence of autism spectrum disorder (ASD) is comparable between boys and girls. The study included a sample of more than 2.7 million people born in Sweden between 1985 and 2020 who were followed from birth to a maximum age of 37. More than 78,000 were diagnosed with ASD. It was observed that boys are usually diagnosed between the ages of 10 and 14, five years earlier than girls. By the age of 20, the proportion of diagnoses is almost equal between the sexes. Before the age of 10, the ratio is 3:1 in favour of boys.

The American Psychiatric Association has unveiled the new features of the forthcoming Diagnostic and Statistical Manual of Mental Disorders (DSM) in five articles published in The American Journal of Psychiatry. Among the highlights are the proposed change of name — it will become the Diagnostic and Scientific Manual — and the intention for it to be more dynamic, incorporating biomarkers for diagnosis and integrating the socioeconomic, cultural and environmental determinants of health. According to the authors, the aim is to enable a more personalised and inclusive clinical practice, aligned with scientific rigour. The most recent update was published in 2022 with the DSM-5-TR, and specialists are currently unaware of the date of the next edition, as they reported during a briefing with journalists.

A meta-analysis published in The Lancet Psychiatry journal concludes that the most effective way to discontinue antidepressant treatment in people with remitting depression is to gradually reduce the dose in combination with psychological therapy. Furthermore, this strategy proved to be just as effective in preventing relapses into depression as continuing medication. The study was based on data from more than 17,000 adults with depression and anxiety in remission, although the evidence for the latter disorder was not as robust. 

Stem cell transplants in cancer patients have achieved complete remission of HIV in a few cases in people who are also HIV-positive. However, in most cases, the donors were homozygous—with two identical copies of the gene—for a mutation in the CCR5 gene that is considered protective against the virus. A German team has now reported a new case of remission in a 60-year-old man with leukemia—called the “second Berlin patient”—in which the donor was heterozygous (only one of the two copies contained the mutation), which could broaden the alternatives. The results are published in the journal Nature.

Consuming up to four cups of coffee a day is associated with an increase in telomere length in people with severe mental disorders, such as schizophrenia or bipolar disorder. Telomere length is an indicator of cellular ageing and is shorter in people with these disorders, although the causes are not clearly understood. According to the study, published in BMJ Mental Health, the effect shown is comparable to ‘a biological age five years younger’ in coffee drinkers. 

The Epstein-Barr virus, which causes mononucleosis, or the kissing disease, is present in approximately 95% of adults. Recent studies have confirmed its link to the vast majority of multiple sclerosis cases. Now, a US team has uncovered a mechanism that would also establish its connection to the development of systemic lupus erythematosus. “We believe it applies to 100% of cases of the disease,” the authors state, publishing their results in the journal Science Translational Medicine.