Eduard Vieta

The U.S. FDA has approved a new drug—called Cobenfy—to treat the symptoms of schizophrenia. Unlike traditional treatments, which are based on blocking the effects of dopamine, its mechanism of action simulates the effects of another neurotransmitter, acetylcholine. It is the first drug to be approved with a different mechanism of action in over 70 years.

The Lancet Psychiatry publishes the first meta-analysis of the incidence of antidepressant treatment discontinuation symptoms that includes data from more than 20,000 patients collected from 79 randomised controlled trials and observational studies. The study sought to distinguish between symptoms directly caused by medication discontinuation and other ‘non-specific’ symptoms that may be associated with patient or professional expectations (the nocebo effect). The study concludes that one in six to seven patients will experience one or more symptoms directly caused by stopping medication, and one in 35 are likely to experience severe symptoms.  

Researchers at Northwestern University in the United States have studied the effect of a temporary decrease in sleep on the mood of mice. According to their results, the animals became more hyperactive and hypersexual for a few hours. In addition, the occasional lack of sleep had an antidepressant effect that lasted for a few days and is explained by an increase in the release of dopamine. The results are published in the journal Neuron.

A commentary published last Friday in the journal Molecular Psychiatry, signed by more than 30 researchers, challenges the conclusions of the systematic review published in the same journal in July 2022, in which the authors concluded that there was no evidence that low serotonin levels cause depression. The researchers in the new paper blame the earlier study for flaws in methodology, among other weaknesses.

Procrastination in a sample of more than 3,500 students was associated with the development of both mental and physical health problems nine months later, according to a study conducted at several universities in Sweden. The results are published in the journal JAMA Network Open.

Two studies published in the journal Nature Communications have found specific characteristics in the microbiota of people with depression, including populations of different ethnicities and habits.

A phase 2 clinical trial has examined the use of the hallucinogen psilocybin in different amounts for the treatment of resistant depression. The results are published in the New England Journal of Medicine.

Research among more than 7,000 US adults shows small changes in extraversion, agreeableness, openness to change and conscientiousness between the period before the covid-19 pandemic and the year 2022, especially in younger people. The study is published in PLOS ONE.

Psychological distress, including depression, anxiety, worry, perceived stress and loneliness, prior to covid-19 infection was associated with an increased risk of persistent covid, according to research published in JAMA Psychiatry.