University of Barcelona

According to a Lancet Public Health commission on commercial gambling, stricter regulations are needed on a global scale to reduce its impact on health and wellbeing worldwide. The authors argue that the harms caused by gambling are a threat to public health, exacerbated by the rapid expansion and digital transformation of the industry. These harms include physical and mental health problems, increased risk of suicide, gender-based violence and financial problems.

The Karolinska Institute has awarded the Nobel Prize in Medicine or Physiology to Victor Ambros and Gary Ruvkun for the discovery of microRNAs, small RNA fragments that do not contain instructions for making proteins but instead participate in the regulation of gene expression. Their role is fundamental in processes such as cell differentiation, and their alteration can influence diseases like cancer.

The U.S. FDA has approved a new drug—called Cobenfy—to treat the symptoms of schizophrenia. Unlike traditional treatments, which are based on blocking the effects of dopamine, its mechanism of action simulates the effects of another neurotransmitter, acetylcholine. It is the first drug to be approved with a different mechanism of action in over 70 years.

The impact of animal abandonment goes beyond the pets who suffer it, it is a public health, safety and funding issue as well. Although there have been some improvements in recent years, the experts consulted agree that the system continues to fail. In this guide, we analyze what has changed, who does this issue affect, and what must be improved.

Both sex and gender are associated with distinct networks in the brains of boys and girls, according to an analysis of brain images of 4,757 children in the US. Understanding these neurobiological patterns is important for identifying how sex and gender influence health and for developing specific diagnostic tools, the research team writes in Science Advances.

The Lancet Psychiatry publishes the first meta-analysis of the incidence of antidepressant treatment discontinuation symptoms that includes data from more than 20,000 patients collected from 79 randomised controlled trials and observational studies. The study sought to distinguish between symptoms directly caused by medication discontinuation and other ‘non-specific’ symptoms that may be associated with patient or professional expectations (the nocebo effect). The study concludes that one in six to seven patients will experience one or more symptoms directly caused by stopping medication, and one in 35 are likely to experience severe symptoms.  

A South Korean research team has designed an artificial olfactory system capable of distinguishing short-chain fatty acids with 90 % reliability. These molecules serve as diagnostic biomarkers for diseases such as stomach cancer and halitosis, according to the authors, whose research is published in Science Advances. The system - consisting of human olfactory receptors, artificial synapses and an artificial neural network - is able to distinguish combinations of molecules, compared to current techniques that detect single molecules and single compounds. 

Hurler syndrome is a rare and very serious disease caused by an enzyme deficiency, which results in a wide variety of signs and symptoms. Treatment with bone marrow transplantation helps to alleviate some of them, but has little effect on skeletal disorders. Now, a phase I/II trial has tested an autologous transplant of blood stem cells corrected by gene therapy in eight patients. The results, published in the journal Science Translational Medicine, suggest that the treatment is more effective and could also improve these types of disorders. 

This Friday, the Interterritorial Council of the National Health System approved the Comprehensive Plan for the Prevention and Control of Smoking (PIT). The document, which incorporates 147 proposals from the autonomous communities, has not achieved consensus among all of them.
 

10 % of people are left-handed, which occurs when the right cerebral hemisphere is more dominant for the control of that hand - whereas it is the left hemisphere in the case of right-handed people. To investigate the genetic basis of this laterality, scientists in the Netherlands have analysed genome data from 350,000 people in the UK biobank for rare genetic variants associated with this phenomenon. The heritability of left-handedness due to rare coding variants was low, at less than 1%. The research, published in Nature Communications, suggests that one gene - TUBB4B - is 2.7 times more likely to contain rare coding variants in left-handed people.