IDIBAPS
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Head of the Cardiology Department at the Hospital Clínic de Barcelona and researcher at the National Centre for Cardiovascular Research (CNIC) and at the August Pi Sunyer Biomedical Research Institute (IDIBAPS)
Senior scientist at the Institute for Biomedical Research of Barcelona (IIBB-CSIC), principal investigator at CIBERSAM and head of the Systems Neuropharmacology group at IDIBAPS-Fundació Clínic.
Researcher at the Reference Unit of Child Psychiatry and Psychology of the August Pi i Sunyer Biomedical Research Institute (IDIBAPS)
Psychiatrist and head of the Imaging of Mood and Anxiety Disorders research group at IDIBAPS
Research Professor at IDIBAPS-Hospital Clínic de Barcelona and Scientific Director of CIBEREHD - Carlos III Health Institute
Clinical psychologist at the Psychiatry and Psychology Service of the Hospital Clínic de Barcelona and member of the research group Imaging of mood and anxiety disorders at IDIBAPS
In a group of people at high cardiovascular risk, low to moderate wine consumption was associated with fewer cardiovascular events (cardiovascular death, myocardial infarction, stroke or heart failure), according to a study. The analysis uses urinary concentrations of tartaric acid, a substance found in grapes and grape derivatives, as a biomarker of wine consumption. It finds that consuming between three and 35 glasses per month was associated with fewer cardiovascular events than in people who consumed fewer than three or more than 35 glasses. The study, published in the European Heart Journal, included more than 1,200 participants from Spain's PREDIMED study with an average age of 68 years.
A phase 2 clinical trial has tested the efficacy and safety of a transcranial magnetic stimulation device used at home to treat major depression in 174 patients. After dividing them into two groups, one group received the treatment and the other a placebo procedure. After ten weeks, both groups had improved their symptoms, but the improvement in the active treatment group was 0.4 points greater on the Hamilton depression scale. According to the authors, who publish the results in the journal Nature Medicine, ‘it could potentially serve as a first-line treatment for major depression’.
The mental health of young people has deteriorated over the last two decades and is entering a dangerous phase, according to a new Commission by The Lancet Psychiatry. Several global factors are involved, including inaction on climate change, intergenerational inequality, and adversity linked to the COVID-19 pandemic.
Five out of ten potential treatments move from animal studies to human studies; four to randomised controlled clinical trials; and one in 20 moves on to approval by regulatory agencies, an analysis estimates. Concordance between positive results in animals and in clinical studies is 86%, according to the study, published in PLoS Biology, which pools the findings of 122 published studies on 54 different human diseases.
A Finnish study involving more than 700,000 adolescents has found some risk of transmission of some mental disorders among classmates. The results are published in the journal JAMA Psychiatry.
The largest meta-analysis to date that studies the risk of children of people with a mental disorder also suffering from some type of mental disorder during their lifetime has been published, with Spanish participation. According to the study, the risk is more than double that of the rest of the population. To explain the study and resolve any doubts that may arise, the Science Media Centre Spain organised an information session with one of the authors, psychiatrist Joaquim Raduà.
An international team, led by the Hospital Clínic-IDIBAPS in Barcelona together with King's College London (UK) and Dalhousie University (Canada), has published the largest meta-analysis to date studying the risk of children of people with mental disorders developing the same, or another type of disorder. The study included more than three million children of parents with different types of disorders and more than 20 million people as a control population. The results, published in the journal World Psychiatry, indicate that, overall, the former have a 1.5 to 3 times higher risk of developing a disorder in their lifetime. According to the authors, in the case of bipolar, depressive or anxiety disorders, the risk of their offspring suffering from some type of disorder is more than 50%.
Apps developed to treat depression may be beneficial in the management of severe and moderate cases. This is the conclusion of a review and meta-analysis that included 13 studies with up to 16 different apps. The results are published in the journal JAMA Network Open.
A study in mice found "mild metabolic and neuropsychological malprogramming" in the offspring of females who, during gestation and lactation, had ingested emulsifiers, substances used to improve the texture of ultra-processed foods. The article, led by a team from IDIBAPS in Barcelona and published in PLoS Biology, states that the consumption during these periods of carboxymethylcellulose and polysorbate 80 - two common emulsifiers - diluted in water was associated with metabolic and cognitive deficits in the mouse offspring.
A phase 1 clinical trial has tested the use of psilocybin to treat anorexia nervosa. Ten women with the disorder were given 25 milligrams of the hallucinogen along with psychological support. The results show that the treatment is safe and tolerable. Four patients showed an improvement, but the authors acknowledge that, because of the small sample size and the absence of a control group, "the results are preliminary and further research is needed". The results are published in the journal Nature Medicine.