Héctor Busto Sancirián

A research team describes in the journal Science how to create organic molecules whose geometry breaks the so-called Bredt's rule. According to this 1924 rule, double bonds between two carbon atoms cannot exist at certain positions in a molecule. Until now, this rule has limited the types of molecules that scientists can imagine and make.

The Nobel Prize in Chemistry 2022 has been awarded to Barry Sharpless and Morten Meldal for laying the foundations of click chemistry, which quickly and efficiently joins molecular building blocks; and to Carolyn Bertozzi, who pioneered bioorthogonal reactions, which use this technique inside living organisms without altering the chemistry of the cell.