E-cigarettes have burst into our society in recent years, supported by a very powerful marketing campaign. From the perspective of the scientific community, a certain division has been created between those who fear that the dissemination of their use may pose a risk to public health and a setback in the denormalisation of smoking, and those who think that e-cigarettes may have a role to play as a tobacco harm reduction strategy. In any case, it is unquestionable that e-cigarettes are not harmless and contain different potentially toxic substances, some common to conventional cigarettes (even if the concentration is lower), and others of their own.  

One of the barriers facing research is the huge variety of aerosols available on the market for consumption in the form of e-cigarettes, with or without nicotine, with or without certain additives, etc. Generating evidence on the toxicity of e-cigarettes is essential to avoid what has already happened with conventional tobacco.  

In the present study, the authors performed an experimental model in mice to evaluate the effect of different aerosols on the electrophysiological properties of the myocardial cell, corroborating previous evidence that attributed to these aerosols a potential effect on autonomic regulation and demonstrating proarrhythmic effects with the capacity to induce ventricular arrhythmias, which are potentially malignant. Although animal models do not guarantee an exact translation to humans, they are hypothesis-generating and should be taken into account in generating caution about the potential cardiac toxicity of these popularised products. Therefore, it is also important that the results are disseminated to the scientific community, health authorities and potential users of these products.