It is a high quality study and is in line with previous work by this group. Research on the function of brown adipose tissue, also known as brown fat, as a possible target for the prevention and treatment of obesity, is opening up new lines of research in cardiovascular disease. 

At present, it is known that activating brown fat could prevent weight gain and even reduce weight in people with obesity. However, so far, all attempts to do so with drugs have not been very successful. Although it has been shown that they can activate brown fat, they generate numerous undesirable side effects, especially at the cardiac level. Therefore, it is important to understand the molecular mechanisms that lead to brown fat activation. This article also provides novelty by proposing a mechanism that could be independent of the activation of the uncoupling protein UCP1, a classic protein involved in the activation of brown adipose tissue. Other authors have already described these non-canonical pathways of UCP1-independent thermogenesis (Biochem J (2020) 477 (3): 709-725, I have no conflicts), and this study could be a new pathway to consider.   

[Regarding limitations] Studies of thermogenesis and brown adipose tissue in animals limit research to what can actually occur in humans. However, these studies provide insight into new metabolic pathways that have yet to be discovered in humans. These new pathways and possible targets may be the starting point for the development of new drugs, as has been the case with the GLP-1 receptor agonists that have emerged in recent years to combat diabetes and obesity. And not only in obesity disease, but also in cardiovascular diseases associated with an increase in adipose tissue, as may occur in age-related metabolic complications (the latter has been studied by us and published in the journal Aging Cell).