A team of researchers has managed to combine more than seven synthetic chromosomes made in the laboratory in a single yeast cell. This involves developing for the first time a eukaryotic cell with more than 50% synthetic DNA, which survives and replicates in a similar way to wild yeast strains. The results, which are part of the Synthetic Yeast Genome Project (Sc2.0), are published in the journal Cell.
The database with the predicted 3D structures of almost all catalogued proteins has just been published. The impact on biology is incalculable, from the development of a vaccine against malaria, to understanding Parkinson's disease, the health of honeybees or the fight against plastic pollution.
A study published in Nature identifies a metabolite produced during exercise that can effectively reduce food intake and obesity in mice. It has also been found in humans.
Whole genome analysis of more than 12,000 tumors has identified new patterns of mutations associated with specific cancers. These combinations generate specific mutational signatures, the study of which provides information on environmental factors causing the mutations. The work is published in Science.