Rey Juan Carlos University

One of the problems with prostate cancer screening is that it results in a high rate of false positives, that is, erroneous diagnoses in people without the disease. A study in the UK has applied a genetic test to more than 6,000 people aged between 55 and 69, analysing 130 variants related to this tumour, which allows a ‘risk score’ to be calculated. According to the results, which are published in the journal NEJM, the test detected the disease more likely in people with higher values than traditional screening.

As announced, the new US president, Donald Trump, has signed on his first day in office an executive order for the United States to withdraw from the Paris Agreement. This is the second time Trump has withdrawn his country from the signatory states of the most important climate change agreement, as he did in 2020.

A study led by CNIO and CNIC researchers has identified a new mechanism in mice by which brown fat can be activated and consume energy to be released as heat. The process depends on a protein called MCJ which, according to the researchers, is “a promising target for treating obesity”. The results are published in the journal Nature Communications. 

Next Monday sees the start of COP29 in Baku, the capital of Azerbaijan, a summit marked by Donald Trump's victory as president of the United States on Tuesday. His denial of climate change and his commitment to fossil fuels during his previous term in office will weigh down a meeting from which no major agreements are expected and from which experts are calling for greater ambition. 

Prostate cancer screening tests using PSA (Prostate Specific Antigen) are associated with overdiagnosis, which calls into question their use. A clinical trial in men aged 50-60 years published in the journal NEJM has studied the possibility of adding an MRI test in those with an elevated PSA level and dispensing with biopsy if imaging finds no suspicious lesions. The results indicate that the procedure avoids more than half of clinically irrelevant cancer diagnoses that would not need treatment and only slightly increases the risk of failing to identify those that may become incurable. The authors recommend, on the basis of the study, to review the recommendations for such screening.

With summer, the presence of these gelatinous creatures on the Spanish coasts bothers swimmers, who can suffer injuries if they come in contact with them. Are there more jellyfish than before? Which ones are the most dangerous? What should I do if one stings me? How can I avoid it? In this guide, we answer the main questions on jellyfish so you know how to act. 

A treatment using lights and sound pulses can protect mice from cognitive decline associated with chemotherapy, according to a research team at the Massachusetts Institute of Technology in the US. The benefits are greatest when the therapy is used early and preventively at the same time as chemotherapy, says the study, published in Science Translational Medicine. The use of this non-invasive sensory stimulation therapy to alleviate other pathologies has already been studied.

After an intense night of negotiations in Dubai (United Arab Emirates), the countries participating in COP28 reached a historic agreement by mentioning for the first time "moving away from fossil fuels" in the Global Stocktake document - the assessment of progress made towards achieving the climate goals set out in the Paris Agreement. The agreement comes after the first draft presented by the presidency did not make this mention - it referred only to "reducing consumption and production" of these fuels - which was described as "unacceptable" by countries such as Spain.

An analysis of data published in the journal General Psychiatry with more than 66,000 diagnoses of gender dysphoria, mostly made in the United States, concludes that prevalence increased between 2017 and 2021, and that the median age decreased over the same period from 31 to 26 years.

Most high-income countries do not have prostate cancer screening programmes for their entire population; prostate-specific antigen (PSA) tests can be done on an individual basis. In an opinion piece published in The BMJ, a group of urologists and epidemiologists specialised in prostate cancer screening argue for restricting the use of PSA tests to avoid over-detection and over-treatment.