Víctor Briz

A study published in PLOS Biology analysed whether supplementation with zinc, serine and branched-chain amino acids —valine, isoleucine and leucine— improves autism-related symptoms in three mouse models. These nutrients are believed to regulate synaptic formation and activity. The results show that the combination of the three nutrients, at low doses for seven days, improved affected brain traits —such as hyperactivity and hyperconnectivity of the amygdala— and the social behaviour of the animals. Individual supplementation did not show such improvements. 

A team has analysed estimated data on exposure to pollution during and after pregnancy and its possible link to a diagnosis of autism in more than two million births in Canada between 2002 and 2022. Their findings are that greater exposure to small PM_2.5 particles containing sulphate or ammonium is associated with a higher likelihood of receiving a diagnosis of autism in the first five years of life. A slightly increased proportion was also observed with greater exposure to ozone during certain weeks of pregnancy and in the first year of life. The results are published in the journal JAMA Network Open.

The PsychENCODE consortium, established in 2015 and dedicated to illuminating the molecular mechanisms underlying schizophrenia, bipolar disorder, and autism spectrum disorder, presents findings based on the examination of human brains at the cellular level. The studies are published today in the journals Science, Science Translational Medicine and Science Advances.

Chronic exposure to various air pollutants has been linked to an increased risk of stroke, but the short-term effects have been less well studied. A review of 110 papers and more than 18 million stroke cases shows that recent exposure - in the five days prior to stroke - also increases the likelihood of stroke. The results are published in the journal Neurology.

An international group of researchers has conducted an epidemiological study to investigate the correlation between fine particulate matter (PM2.5) air pollution and certain types of lung cancer. The authors have confirmed their findings in animal models, according to research published in Nature.

Air pollution has been repeatedly linked to the risk of developing dementia. In addition to confirming this association, a study published in the journal PNAS has analysed the individual risk posed by the components present in PM2.5 fine particulate matter.

Two researchers propose that the anti-diarrhoeal drug Loperamide could be a candidate for treating the main symptoms of autism spectrum disorder (ASD), such as difficulties in social interaction and communication. The research, published in the journal Frontiers in Pharmacology, has used a computer model that includes the proteins involved in ASD and has analysed how different drugs affect them.

A study published in Cell Reports shows that air pollution and stress during pregnancy disrupt the brain wiring of developing male and not female mice, causing autism-like social behavior in them.