University of Jaén

In the treatment of obesity, maintaining weight loss is the most difficult phase. Two independent clinical trials published in Nature Medicine have adopted two different strategies to achieve this. The first is a phase 3b trial involving the GLP-1 drug orforglipron, administered orally on a daily basis for 52 weeks. This trial included 376 adults in the United States who had already completed 72 weeks of injectable treatment with tirzepatide or semaglutide. Almost 75% and 80% respectively of patients on each injectable drug maintained their weight loss. The second trial involved 90 obese adults from the Netherlands who followed a low-calorie diet for eight weeks and then received a daily supplement of the bacterium Akkermansia muciniphila for 24 weeks, alongside a healthy diet. Although those who received the supplement regained more than 13% of the weight initially lost, those who took the placebo regained almost 33%.

A study with Spanish participation has discovered in mice that semaglutide can improve the condition of non-alcoholic fatty liver disease not only through weight loss, but also independently, which would explain why some patients improve with minimal weight loss. “We are not saying that weight loss is unimportant, as many things improve when patients lose weight. But now we know that weight should not be the only measure of success, because GLP-1 drugs will improve liver health regardless of whether the patient loses weight or not,” the authors, who published the results in Cell Metabolism. 

The journal Science has published a review of the emerging use of artificial intelligence (AI) in mental health treatment, with examples such as conversational bots for reducing depressive symptoms. The authors defend the usefulness of this technology in the different stages of psychological care, provided that the human factor, both on the part of the clinician and the patient, is the leading factor in the approach. In this regard, they emphasise that AI cannot replace clinical judgement. The distinctive characteristics of psychological care, such as the disclosure of personal information by vulnerable individuals, also necessitate regulatory frameworks that ensure ‘the ethical and effective implementation of AI technologies’.

An artificial intelligence (AI) model led by the company Meta is capable of translating speech and text, including direct speech-to-speech translations, from up to 101 languages in some cases. According to the research team, this model - called SEAMLESSM4T - can pave the way for fast universal translations ‘with resources to be made publicly available for non-commercial use’. The work is published in the journal Nature.

The Royal Swedish Academy of Sciences has awarded the Nobel Prize in Physics 2024 to researchers John J. Hopfield and Geoffrey E. Hinton for discovering the foundations that enable machine learning with artificial neural networks. Hinton for discovering the foundational basis that enables machine learning with artificial neural networks. This technology, inspired by the structure of the brain, is behind what we now call ‘artificial intelligence’. 

Burying woody biomass in wooden vaults would allow carbon to be extracted and stored from the atmosphere, according to a study published in Science. The authors were inspired by an eastern red cedar log preserved underground for more than 3,700 years in Canada. The team proposes burying wood from sustainable sources in a domed wooden structure designed to extend the duration of carbon storage. The authors estimate that up to 10 gigatonnes of CO₂ could be sequestered annually using this technique.

An international team of researchers has studied 241 brain-damaged people apparently unable to respond to external stimuli. Using techniques such as functional magnetic resonance imaging and electroencephalogram, they have detected signs of brain activity in 25 % of them that, according to the authors, ‘suggest that they may be interacting with the outside world’. The results are published in the journal NEJM.