Intermittent fasting is not as effective for weight loss in obese or overweight individuals, according to a meta-analysis

A meta-analysis published in the Cochrane Database of Systematic Reviews concludes that intermittent fasting is not particularly effective for weight loss in adults who are obese or overweight, who showed moderate weight loss. This strategy also does not differ significantly from standard dietary advice or improvement in quality of life. The review included 22 studies with nearly 2,000 participants and evaluated various forms of intermittent fasting, including restricting food intake for most of the day and fasting every other day.

 

16/02/2026 - 02:00 CET
Expert reactions

Francisco J. Tinahones - ayuno intermitente EN

Francisco J. Tinahones

President of the SEEDO Foundation and the Spanish Society of Endocrinology and Nutrition (SEEN)

Science Media Centre Spain

The article does not say that intermittent fasting is not effective for weight loss. What it does say is that, based on the studies included so far, there is no evidence that it is superior to classic calorie restriction in terms of weight loss. Most researchers agree on this point and on the need for more clinical trials of longer duration to see if it really offers more benefits than the classic low-calorie diet.

But we do have evidence that it is an alternative for weight loss that is, at a minimum, as effective as classic calorie restriction.

The study is an analysis of clinical trials to date comparing intermittent fasting with the classic diet. There are currently many trials underway and others that have been recently published that have probably not been included.

The author has not responded to our request to declare conflicts of interest
EN

Ana Belén Crujeiras - ayuno intermitente EN

Ana Belén Crujeiras Martínez

Member of SEEDO and Head of Epigenomics in the Endocrinology and Nutrition Group of the Epigenomics Unit at the Santiago Health Research Institute (IDIS), Santiago University Hospital Complex (CHUS)

Science Media Centre Spain

It is a rigorous review that meets scientific standards for systematic reviews. It suggests that intermittent fasting does not result in greater weight loss than traditional diets. However, the quality of many studies is limited and the follow-up period is short, so it is not the final word.

Intermittent fasting can be useful in many cases; there is scientific evidence to prove this. If intermittent fasting is done correctly, it creates a state of nutritional ketosis that can confer health benefits because ketone bodies have antioxidant and anti-inflammatory properties and are signalling molecules that can modulate epigenetic mechanisms. This state of nutritional ketosis has been observed to be associated with improved well-being and quality of life.

Obesity is a chronic disease that must be addressed in a holistic and multidisciplinary manner. Treatments for overweight/obese individuals must be personalised and tailored to each person; some therapeutic strategies work for some people and others for others, depending on their lifestyle, personal tastes and molecular and physiological profile, and always under the prescription of a nutrition or endocrinology professional.

The author has not responded to our request to declare conflicts of interest
EN
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Cochrane Database of Systematic Reviews
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Luis I Garegnani et al.

Study types:
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  • Peer reviewed
  • Meta-analysis
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