Mice with Alzheimer's disease develop fewer colorectal tumors

Mice with Alzheimer's disease are more resistant to the development of colorectal tumors, a study shows. An inverse relationship between Alzheimer's and cancer has already been shown in epidemiological studies in humans. An imbalance in certain intestinal bacteria contributes to this negative correlation in mice, adds the article published in PNAS.

02/09/2024 - 21:00 CEST
Expert reactions

Alzheimer tumores - Ferrán Catalá

Ferrán Catalá López

Scientist at the Center for Human and Social Sciences, IPP-CSIC, specialized in meta-research in public health, epidemiology and health services.

Science Media Centre Spain

Although [the study is] interesting for its findings, the investigators applied animal models (small sample of mice) for their experiments, so the data in my opinion are preliminary. They should be considered with the rest of the available knowledge on the associations between Alzheimer's disease and cancer, and most importantly, they should be confirmed in further studies in human populations (health care patients).

The author has not responded to our request to declare conflicts of interest
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Publications
Inhibition of colorectal cancer in Alzheimer’s disease is mediated by gut microbiota via induction of inflammatory tolerance
  • Research article
  • Peer reviewed
  • Experimental study
  • Animals
Journal
PNAS
Authors

Nan Zhang et al.

Study types:
  • Research article
  • Peer reviewed
  • Experimental study
  • Animals
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