nutrition

A US research team has identified several genes that may be associated with a strict vegetarian diet. Some of these genes have "important roles in lipid metabolism and brain function", according to the paper, which suggests that these differences could explain the ability to subsist on a vegetarian diet in those who carry these genes. The study, published in the journal PLoS ONE, used data from the UK Biobank to compare a group of more than 5,000 vegetarians with a group of more than 320,000 non-vegetarians.

A study in mice found "mild metabolic and neuropsychological malprogramming" in the offspring of females who, during gestation and lactation, had ingested emulsifiers, substances used to improve the texture of ultra-processed foods. The article, led by a team from IDIBAPS in Barcelona and published in PLoS Biology, states that the consumption during these periods of carboxymethylcellulose and polysorbate 80 - two common emulsifiers - diluted in water was associated with metabolic and cognitive deficits in the mouse offspring.

The International Agency for Research on Cancer (IARC) and the Joint FAO/WHO Expert Committee on Food Additives (JECFA) have published a health impact assessment of the sweetener aspartame. Citing "limited evidence" of carcinogenicity in humans, IARC has classified aspartame as possibly carcinogenic to humans (Group 2B). For its part, JECFA has not changed the acceptable daily intake of this sweetener, which is set at 40 mg/kg body weight. According to these bodies, with one can of diet soft drink containing 200-300 mg aspartame, a 70 kg adult would need to consume more than 9-14 cans per day to exceed the acceptable daily intake - assuming no other intake from other dietary sources.

Reuters has reported that aspartame, one of the most common artificial sweeteners, will be listed as "possibly carcinogenic to humans" by the International Agency for Research on Cancer (IARC), an agency of the World Health Organisation, in July.

The WHO has issued a new guideline advising against the use of non-sweetened sweeteners for weight control or to reduce the risk of noncommunicable diseases. The recommendation is based on the findings of a systematic review published in 2022.

A new scientific statement from the American Heart Association published in the journal Circulation analyzes how several diets (including Mediterranean, Paleo, and ketogenic) fit into the guidelines for a heart-healthy diet. The ketogenic and 'paleo' diets were not classified as heart-healthy.

A study in mice has found that high doses of the sweetener sucralose can reduce the immune response and, under certain laboratory conditions, alter its action against infections or tumours. The results are published in the journal Nature.

A review of studies of more than 700,000 women has estimated that those who follow a Mediterranean diet faithfully have about a 25% lower risk of cardiovascular disease and death. This effect is greater than had been found in other studies, many of which included a majority of men and did not differentiate results by sex. According to the authors, the study underscores the need for this type of targeted analysis. The results are published in the journal Heart.

A study has associated the consumption of the sweetener erythritol with an increased risk of cardiovascular disease, specifically myocardial infarction and stroke. The data are published in the journal Nature Medicine.

Research analysing data from more than 100,000 people in the UK followed for nearly a decade concludes that a higher intake of free sugars - added sugars or those naturally present in honey and fruit juice - is associated with an increased risk of cardiovascular disease. The study is published in BMC Medicine.