Barcelona Supercomputing Center (BSC)

Thirty eight scientists from different specialties, including Craig Venter, a pioneer in the creation of artificial synthetic life, have written an article in the journal Science in which they assess the possibilities of synthesizing mirror organisms, but also warn of the risks they pose. This type of microorganisms, which would present a mirror structure to that currently found in nature, would have potential applications due to their resistance to biological degradation. However, they would also pose a danger because they would not be recognized by our defenses and could spread in ecosystems. Scientists call for more research and a broad debate, and warn that until more is known, this type of organism should not be created. 

In the early hours of the morning, after more than two weeks of negotiations and on the verge of collapse, participants at COP29 in Baku (Azerbaijan) reached an agreement to set the new climate finance target. In the end, at least 300 billion dollars a year will be contributed by rich countries to the least developed countries until 2035, within a broader global commitment of up to 1.3 trillion dollars directed at these same countries. The renewal of this target was part of the Paris Agreement and will enable governments to support developing countries in their climate action on adaptation, mitigation and damage from the climate crisis. The previous target - set at the Copenhagen Summit in 2009 - was $100 billion per year.

Many diseases related to bacteria, such as inflammatory bowel disease or colorectal cancer, are associated with an overgrowth of gut bacteria considered 'bad'. However, a study published in the journal Cell suggests that changes in microbial load, rather than the disease itself, could be the driving factor behind the presence of these harmful species associated with pathologies.

The largest carbon balance report shows that carbon dioxide emissions have not yet peaked and are projected to reach 37.4 billion tonnes by 2024. In a briefing organised by SMC Spain, Pep Canadell, one of the people in charge of the Global Carbon Budget 2024, analysed these data and what Donald Trump's return as US president means for climate action in the framework of COP29 in Baku.

There are still no clear signs that global fossil carbon dioxide (CO₂) emissions have peaked, according to the 2024 Global Carbon Budget. The report - which is published in the journal Earth System Science Data in preprint format and will be launched at COP29 in Baku - estimates that these emissions will grow by 0.8% this year compared to 2023, to 37.4 billion tonnes of CO₂. If this rate continues, there is a 50% chance that global warming will exceed the 1.5°C limit in six years.

A study by a team from the ClimaMeter project claims that the intensification of rainfall from the DANA that devastated Valencia and other regions on 29 October is mainly attributed to human-induced climate change. Natural climate variability, on the other hand, probably played a modest role. According to the analysis, this DANA was driven by very exceptional weather conditions. The work also shows that the DANA-like depressions that cause flooding in the southeastern peninsular are up to 15 % wetter than they were in the past. In addition, temperatures are up to 3°C warmer, which favours storm formation in these events over the Mediterranean basin. 

Two of the Nobel Prize winners in Chemistry 2024 are employees of Google DeepMind, who caused significant unrest among their colleagues in May. Hassabis and Jumper announced in *Nature* the results of their AlphaFold 3 model, with applications in drug design; however, they published it in a closed manner, with reviewers not even having access to the system, which contradicts the basic principles of scientific publication. We risk having the transformative potential of AI controlled by big tech companies.

The Royal Swedish Academy of Sciences has awarded the Nobel Prize in Chemistry 2024 on the one hand to David Baker for computational protein design, which makes it possible to construct proteins with functions not present in nature. On the other hand, jointly to Demis Hassabis and John M. Jumper of Google DeepMind, for the development of AlphaFold2, which allows the structure of the 200 million known proteins to be predicted at high speed. 

Climate tipping points are thresholds at which elements of the Earth could reach a point of no return, accelerated by climate change and with consequences for the rest of the planet. These drastic changes could affect, for example, the Atlantic Meridional Circulation (AMOC), polar ice sheets or tropical rainforests. A study published in Science Advances concludes that there is too much uncertainty to extrapolate historical data and reliably estimate when these inflections will occur.
 

Research has identified 31 biomarkers in the gut microbiota of children that are associated with autism spectrum disorder (ASD) and could have diagnostic value. The gut microbiota includes bacteria, viruses, fungi and archaea. The team replicated the results, published in Nature Microbiology, in three cohorts and analysed faecal samples from more than 1,600 children and children in total, with and without ASD, in China.