University of Navarra

Glutathione is considered an antioxidant due to its ability to repair cellular damage. The body produces it naturally, but it is also sold as an antioxidant supplement. A study in mice and human tissue, published in Nature, shows that cancer cells can break it down and use it as fuel—particularly the cysteine it contains—promoting tumour growth and survival. “Depriving tumours of extracellular glutathione or inhibiting its breakdown is potentially a viable therapeutic strategy for cancer patients,” the authors state.

Physical inactivity driven by rising temperatures due to climate change could result in between 0.47 and 0.70 million additional premature deaths each year by 2050, according to projections from a new study published in The Lancet Global Health. The study analysed data on the relationship between temperature and physical inactivity across 156 countries between 2000 and 2022. Low- and middle-income countries, where access to air conditioning, the availability of shaded public infrastructure, and discretionary leisure time are limited, were the most affected. Spain is among the European countries expected to be most impacted.

On social network X (formerly Twitter), when users select the ‘for you’ option, the algorithm tends to steer them towards more conservative political options, according to research conducted with nearly 5,000 participants in the United States in 2023. The authors randomly assigned users to either an algorithmic or chronological feed for seven weeks. The switch from chronological to algorithmic feed increased engagement and shifted political opinion towards more conservative positions, especially on political priorities, perceptions of criminal investigations into Donald Trump, and opinions on the war in Ukraine. Conversely, switching from the algorithmic feed to the chronological feed had no comparable effects. ‘Initial exposure to X's algorithm has persistent effects on users' current political attitudes,’ say the authors of the study, published in Nature.

A phase 3 clinical trial conducted in China tested 210 patients with advanced non-small cell lung cancer—the most common type—to see whether the time of day when immunotherapy and chemotherapy were administered influenced their effectiveness. The data indicate that, on average, those who received therapy after 3 p.m. did not see their cancer worsen for 5.4 months. In contrast, those who received it before that time did not see their cancer worsen for an average of 11.7 months, almost twice as long. Overall, response rates were 56.2% and 69.5%, respectively. The results, published in Nature Medicine, suggest that scheduling therapy early in the day may offer a simple and cost-free way to improve treatment efficacy.

A study by the University of Cádiz has identified six factors that drive polarization around health-related issues, for example during crises such as the COVID-19 pandemic: political ideology, misinformation, social media dynamics, trust in institutions and professionals, risk perception, and socioeconomic factors. This review, published in Science Advances, brings together the conclusions of 90 previous studies and analyzes how these determinants exacerbate health inequalities and influence compliance with public health measures.

An international team with Spanish participation has analyzed data from more than 500,000 people and found a link between digestive disorders such as colitis, gastritis, esophagitis, or functional bowel disorders and an increased risk of developing Alzheimer's and Parkinson's diseases. According to the researchers, who published their findings in the journal Science Advances, “this effort sheds light on the interaction between factors involved in the gut-brain axis and opens avenues for targeted treatment and early diagnosis.”

A diet rich in omega-3 fatty acids, found mainly in fish oils, may help prevent the development of myopia in children, while high consumption of saturated fats, found in foods such as butter, palm oil and red meat, may increase the risk of developing this condition, according to research published in the British Journal of Ophthalmology. The study was conducted on a thousand children in Hong Kong aged between six and eight.

Certain immunotherapy treatments for cancer work by releasing the brakes on our defences. However, their response varies and is not uniform in all patients. A team in the United States has now published a study in Nature according to which certain autoantibodies present in patients could improve the efficacy of the therapy, which would explain some of this variability and could be used to design future complementary treatments.

Children will suffer more from the climate crisis than their grandparents. Fifty-two per cent of people born in 2020 will experience unprecedented heat waves throughout their lives, compared to 16 per cent of those born in 1960. This was calculated by a study published in Nature last month, assuming that temperatures rise 1.5 °C above pre-industrial levels. In this article, we analyse the profile of children who already suffer from heat in our country and explain how to adapt their environments to extreme temperatures. 

Consumption of ultra-processed food is associated with an increased likelihood of having prodromal signs of Parkinson's disease - symptoms that precede the disease - says a study published in Neurology. The analysis is based on data from more than 42,000 healthcare professionals in the US, followed for up to 26 years.