University of Santiago de Compostela

Although tobacco consumption is declining in many parts of the world, there appears to be an increase in the number of lung cancer cases among non-smokers. One of the possible causes of this increase is air pollution. Now, researchers in the US, with Spanish participation, have analysed the genomes of 871 lung tumours in people from various locations who had never smoked. The results, published in the journal Nature, indicate that greater exposure to pollution is linked to an increase in the number of mutations, including those commonly associated with tobacco.

Competition to attract audiences encourages media outlets to spread misinformation, according to a study published in Science Advances. The research applies a mathematical framework - called a zero-sum game - to analyse the dynamics between immediate media benefits and long-term damage. The model showed how an ‘arms race’ can emerge between news sources: when one player resorts to misinformation, the other has to do the same in order to compete.

In online debates, Large Language Models (LLMs, i.e. Artificial Intelligence systems such as ChatGPT) are more persuasive than humans when they can personalise their arguments based on their opponents’ characteristics, says a study published in Nature Human Behaviour which analysed GPT-4. The authors urge researchers and online platforms to ‘seriously consider the threat posed by LLMs fuelling division, spreading malicious propaganda and developing adequate countermeasures'.

Research has analyzed how extreme heat influences the biological age of elderly populations, specifically in the United States. The study, published in Science Advances, used blood samples from more than 3,600 adults with an average age of 68 collected between 2010 and 2016. The team compared epigenetic aging trends with the number of days of extreme heat in the participants' places of residence. The models showed that more days of heat or long-term heat — over a period of one to six years — increased the biological age of the participants by more than two years.

A team of researchers led by the Max Planck Institute for Evolutionary Anthropology in Germany has analysed nearly 10,000 ancient genomes and found six cases of people with Down's syndrome and one with Edwards' syndrome. Most of them died before or shortly after birth. The findings correspond to different periods up to 5,500 years old and several of them have been found in Navarra. According to the authors, "the care with which the burials were carried out and the objects found with these individuals indicate that ancient societies probably treated people with trisomies 18 and 21 as members of their communities". The findings are published in Nature Communications.

E-cigarettes combined with traditional therapies are more effective for smoking cessation than regular therapies alone, says a study conducted in Switzerland and published in the New England Journal of Medicine. The study involved two groups of about 600 participants each. At a 6-month control visit, 59.6% of the members of the e-cigarette group had not smoked tobacco in the previous week, compared to 38.5% in the control group.

For the treatment of many diseases it is necessary to use large molecules that do not resist the digestion process and must be injected. Now, a group of scientists at the Institute of Chemical Sciences and Engineering in Lausanne (Switzerland) has developed a method for synthesizing a type of protein called cyclic peptides, capable of binding to varied and complex targets, and they have done so in a way that makes them capable of being administered orally. According to the press release accompanying the publication, this opens "a new era in drug development".

According to a survey conducted in Spain, with 403 respondents from the biomedical research field, four out of ten admit to having committed some type of misconduct in their work. The press regularly reports on scandals in science. Among the most recent cases, El País reported that the CSIC has opened a disciplinary proceeding against five individuals suspected of receiving money in exchange of false affiliations. These cases of misconduct may seem isolated, but they reflect broader dysfunction of the research system. In this guide, we provide keys to better understand how these cases arise and evolve, and to cover their nuances. 

A research project has analysed the Twitter discourse related to deepfakes in the context of the Russia-Ukraine war in 2022, studying almost 5,000 tweets related to these videos. Deepfakes are synthetic media that mix an original video with content generated by artificial intelligence, often with the aim of mimicking a person. The research, published in PLoS ONE, looks at the lack of literacy about deepfakes and the scepticism and misinformation that can arise when real media is mistakenly identified as fake. The authors warn that efforts to raise public awareness of this phenomenon can undermine trust in other legitimate media, that can also be seen as suspect.

Research has compiled data on brewing hop yields and alpha content - which gives beer its bitter aroma and affects quality - between 1971 and 2018 in hop-growing areas of Germany, the Czech Republic and Slovenia. The results, published in the journal Nature Communications, show that, compared to 1994, hop production has decreased by 0.2 tonnes per hectare per year and alpha bitterness content has fallen by 0.6%. Combining the data with climate models, the authors estimate that by 2050 hop yields and alpha content will fall by 4 - 18% and 20 - 31% respectively. According to the models, the cause will be higher temperatures and more frequent and severe droughts due to climate change.