bioinformatics

The Royal Swedish Academy of Sciences has awarded the Nobel Prize in Chemistry 2024 on the one hand to David Baker for computational protein design, which makes it possible to construct proteins with functions not present in nature. On the other hand, jointly to Demis Hassabis and John M. Jumper of Google DeepMind, for the development of AlphaFold2, which allows the structure of the 200 million known proteins to be predicted at high speed. 

A clinical trial involving 60 people with upper and lower body paralysis showed that a non-invasive electrical spinal cord stimulation device - called ARCEX - helps improve hand and arm function in quadriplegic patients. The study, the results of which are published in Nature Medicine, showed that 43 of the people with paralysis experienced improved arm and hand strength and function after receiving electrical stimulation along with rehabilitation exercises.  

Meta has applied language modelling to predict the structure of a large collection of proteins. The model, called ESMFold, is being presented this week in the journal Science after being published on the bioRxiv preprint article server in December 2022. EMSFold is faster than similar models such as AlphaFold, developed by Google's DeepMind and EMBL's European Bioinformatics Institute. The sequences of more than 617 million proteins - of which more than a third are predicted with a high degree of confidence - are published in open access in the ESM Metagenomic Atlas.