Rafael Matesanz

Currently, when an organ transplant is performed, the patient has to take immunosuppressive drugs to prevent his or her system from rejecting the new organ. These drugs must be taken for life and have numerous side effects. In a phase 1 clinical trial, researchers gave patients receiving a liver transplant regulatory dendritic cells derived from the original donor, with the hypothesis that these cells could 'teach' the recipient's immune system to tolerate the new organ. The research, published in Science Translational Medicine, suggests that this treatment could reduce or even eliminate the need for long-term use of immunosuppressants.

Scientists have successfully developed pig embryos whose kidneys contain 50-60% human cells. Gestation was terminated at 25-28 days, and the organ structure was normal. According to the press release accompanying the article, "this is the first time that a solid humanised organ has been grown inside another species, although previous studies have used similar methods to generate human tissues". The results are published in the journal Cell Stem Cell. 

Researchers have developed a system capable of restoring some molecular and cellular functions and preserving tissues in pigs when initiated one hour after death. The study is published today in the journal Nature.