CIBERobn

Children whose mothers took high doses of vitamin D (2,800 IU/day) during pregnancy have better verbal and visual memory at the age of 10—among other cognitive functions—than children whose mothers took a standard dose of this vitamin (400 IU/day). This is the conclusion of a study, published in JAMA Network Open, based on a reanalysis of data from 498 children in another study on childhood asthma in Denmark.

A global analysis of data from more than 232 million people shows that the rise in obesity has slowed or stabilised in some high-income countries since the 1990s among children and adolescents, and, a decade later, among adults. In Spain, this stabilisation or even a slight decline is also observed. In most low- and middle-income regions, the prevalence of obesity continues to increase and, in some cases, has already surpassed that of more developed economies. The study, published in Nature, included 4,050 studies covering the period from 1980 to 2024 across 200 countries.

One of the best-known genetic risk factors for developing Parkinson’s disease is carrying variants of the GBA1 gene. A new study published in the journal Nature Medicine compared the microbiomes of 43 carriers of this gene who had not developed the disease with those of 271 Parkinson’s patients and 150 healthy individuals. The results showed, in addition to alterations in the microbiome in the patient group, that 25% of the microbiome of carriers of this gene exhibited alterations, representing an intermediate profile between the other two groups. The results were validated using independent cohorts from the United Kingdom, South Korea, and Turkey. According to the authors, “alterations in the gut microbiome can identify individuals with both genetic and non-genetic risk in the general population who may be progressing toward Parkinson’s disease.”
 

GLP-1 medicines for the treatment of obesity show considerable variability between individuals. Using data from 23andMe, scientists at this genetic testing company conducted genome-wide association studies in nearly 28,000 people treated with these drugs, analysing self-reported weight loss and adverse effects. Their findings, published in Nature, identified variations in two genes involved in gut hormone pathways that regulate appetite and digestion, although the authors caution that the effects of genetics appear to be modest.

Adopting a healthy diet at age 45 can add between two and three years to life expectancy in men, and between 1.5 and 2.3 years in women, according to a study based on data from more than 103,000 people in the United Kingdom. The positive impact is greater for men who follow a diabetes risk reduction diet (DRRD) and for women who follow a Mediterranean-style diet (AMED), says the article published in Science Advances.

An international team has analyzed data from nearly 60 studies involving more than 48,000 children with different types of diets and compared the nutritional profile and various health parameters between those following vegan, lacto-ovo-vegetarian, and omnivorous diets. The results indicate that plant-based diets, if well-planned, can promote healthy growth with benefits such as a better cardiovascular profile and lower cholesterol levels. However, they may have difficulty achieving adequate levels of vitamins D and B12, calcium, iron, and zinc. According to the authors, the findings underscore the need for careful planning and supplementation in children following these types of diets. The study is published in Critical Reviews in Food Science and Nutrition. 

The prevalence—proportion of cases—of hypertension in minors has almost doubled worldwide between 2000 and 2020, rising from 3.4% to 6.53% in boys and slightly less in girls, according to a systematic review published in The Lancet Child & Adolescent Health. The study brings together data from nearly 444,000 children and adolescents up to the age of 19 in 21 countries.

The Planetary Health Diet promotes environmentally sustainable consumption, based, among other things, on increasing vegetable intake and reducing dairy and red meat consumption. Previous studies had found an association with better human health, although there were some conflicting results. Now, a study combining two cohorts of more than 150,000 people and a meta-analysis of 37 studies involving more than three million volunteers reinforces this association, finding that greater adherence to the diet is associated with lower all-cause mortality. The results are published in the journal Science Advances.

Consumption of ultra-processed food is associated with an increased likelihood of having prodromal signs of Parkinson's disease - symptoms that precede the disease - says a study published in Neurology. The analysis is based on data from more than 42,000 healthcare professionals in the US, followed for up to 26 years.

Consuming certain mixtures of common food additives is linked to a slightly increased risk of developing type 2 diabetes, according to an analysis of data from more than 108,000 adults in France. The study, published in PLoS Medicine, identified five mixtures of additives frequently used in ultra-processed foods and concluded that two of them are associated with the disease: the first mixture consisted mainly of emulsifiers, preservatives and a colouring agent, and the second of acidifiers, acidity regulators, colouring agents, artificial sweeteners and emulsifiers.