Gregorio Marañón University Hospital
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Neurologist at the Centro de Ictus of the Gregorio Marañón General University Hospital
Head of the Department of Child and Adolescent Psychiatry and Director of the Institute of Psychiatry and Mental Health of the Hospital General Universitario Gregorio Marañón
Endocrinology Specialist at the Endocrinology and Nutrition Service of the Hospital General Universitario Gregorio Marañón and Director of the SEEN-University of Barcelona-Editorial Panamericana University Expert Course in Transgender Medicine
Doctor at the Paediatrics Department of the Gregorio Marañón University Hospital and coordinator of the PedGAS-net Project -a national network for the study of invasive S. pyogenes infections-
Head of the Medical Oncology Department of the Gregorio Marañón Hospital and president of GEICAM
A team of researchers from the United Kingdom has conducted a phase 2/3 clinical trial in people with a psychotic disorder to study the efficacy of interaction with a digital avatar in alleviating the discomfort generated by hearing voices. After analyzing it in 345 people, they conclude that it can reduce the frequency of occurrence at 16 and 28 weeks. The discomfort provoked is reduced at 16 weeks, but not at 28 weeks. The team publishes the results in the journal Nature Medicine.
The U.S. FDA has approved a new drug—called Cobenfy—to treat the symptoms of schizophrenia. Unlike traditional treatments, which are based on blocking the effects of dopamine, its mechanism of action simulates the effects of another neurotransmitter, acetylcholine. It is the first drug to be approved with a different mechanism of action in over 70 years.
The number of people who suffer a stroke, die from it or live with a subsequent disability has risen sharply worldwide between 1990 and 2021, according to a study published in The Lancet Neurology. The contribution of high temperatures to ill health and premature death from stroke has increased by 72% since 1990. For the first time, the study reveals the high contribution (on par with smoking) of particulate air pollution to subarachnoid haemorrhage (fatal brain haemorrhage).
A team of researchers at Stanford University (USA) has developed a technique that makes animal tissues transparent in vivo and reversibly. Based on a food dye, they have tested it topically on mice. According to the authors, who publish their research in the journal Science, “this technology could make veins more visible for blood collection or help in the early detection and treatment of cancer”.
The mental health of young people has deteriorated over the last two decades and is entering a dangerous phase, according to a new Commission by The Lancet Psychiatry. Several global factors are involved, including inaction on climate change, intergenerational inequality, and adversity linked to the COVID-19 pandemic.
Although breast cancer mortality has reduced by more than 40% in most high-income countries, a Lancet commission warns that one million people will die from the disease by 2040, especially in low- and middle-income countries. The authors highlight some of the knowledge gaps that persist about the disease, such as the lack of knowledge about the number of patients living with metastatic breast cancer and their needs, or the costs associated with breast cancer - including physical, psychological, social and economic costs - which, according to the authors, are immense but underestimated, and not adequately reflected in global health indicators.
A study published in JAMA Network Open has followed 1,340 women with high-risk operable breast cancer. Analysing their lifestyles before, during and after treatment, the researchers conclude that those who followed a healthier pattern - including physical activity, no smoking, high fruit and vegetable intake, and low consumption of meat and sugary drinks - had a 37% lower risk of relapse and a 58% higher chance of survival than those who followed a worse pattern. Although the improvements in absolute risk were much smaller, the authors conclude that "lifestyle interventions may be a safe, inexpensive and feasible adjuvant strategy to delay and prevent recurrence and death from the world's most common cancer".
A study published today in the NEJM examines the risk of relapse in breast cancer patients who decide to pause endocrine therapy to try to become pregnant. The results show that temporarily stopping treatment does not confer an increased risk in the long term, but the authors warn of the need for further follow-up.
A phase 2 clinical trial has tested a type of immunotherapy based on oncolytic viruses in combination with chemotherapy for the treatment of triple-negative breast tumours. The results are published in the journal Nature Medicine.
Physical activity is associated with significant reductions in depressive symptoms in children and adolescents, according to a systematic review and meta-analysis published in JAMA Pediatrics that included 21 studies with 2,400 participants. The largest decreases in these symptoms were found in those aged 13 years and older.