Health Institute Carlos III
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Head of the Influenza and other Respiratory Virus Surveillance Group of the National Epidemiology Centre.
Researcher at the Reference and Research Laboratory in Mycology, National Microbiology Centre, Instituto de Salud Carlos III
Senior Scientist at the Health Institute Carlos III
Researcher in social epidemiology, public health and biostatistics
Co-director of the Reference Unit on Climate Change, Health and Urban Environment of the Carlos III Health Institute
Researcher at the National Center for Microbiology - Carlos III Health Institute
Senior scientist at the Reference Laboratory for Influenza and Respiratory Viruses of the National Microbiology Centre.
Associate Professor of Epidemiology at the Autonomous University of Madrid (UAM) and Research Scientist at the National Epidemiology Centre (Carlos III Health Institute)
Head of the Respiratory Virus and Influenza Research Group of the Carlos III Health Institute
Full university professor at the Central University Hospital of Asturias, scientific director of the Principality of Asturias Biobank (BioPA) and coordinator of the Organoid Hub of the National Platform of Biobanks and Biomodels of the ISCIII
Although outbreaks of H5N1 avian influenza have reached record numbers in recent years, human infections remain anecdotal. A study published today in Nature identifies a protein responsible for inhibiting the replication of this virus in humans, while 'human' flus are able to evade it. The authors propose that this protein with antiviral activity evolved in primates and consider that resistance or sensitivity to it should be taken into account when assessing the zoonotic potential of avian influenza viruses.
On 5 April, the UK National IHR Focal Point informed WHO of an increase in severe myocarditis in neonates associated with enterovirus infection in Wales (UK). Between June 2022 and April 2023, ten hospitalised neonates with a positive PCR for enterovirus were found to have myocarditis. Seven of the ten cases were confirmed to have coxsackievirus B3 or coxsackievirus B4. As of 5 May 2023, one patient remained hospitalised and one patient had died. According to the WHO statement, although enterovirus infections are common in neonates and infants, the reported increase in myocarditis - inflammation of heart muscle tissue - with severe outcome associated with enterovirus infection is unusual.
A drug in gel form cured 100 percent of mice with a very aggressive brain tumor. The authors hope that this is a first step towards helping human patients with glioblastoma, one of the most dangerous brain tumors in humans. The article is published today in PNAS.
A study published in the journal Science Translational Medicine shows the results of a phase 1 trial of a new broad-spectrum influenza vaccine. Prepared in the form of nanoparticles containing the H1 hemagglutinin stem-a region that is often conserved in different subtypes of the virus-the vaccine was generally well tolerated by participants, who showed only mild side effects such as tenderness and headaches. The prototype generated an antibody response to group 1 influenza viruses in all age groups.
Between 10-15% of childhood brain tumours are diffuse midline gliomas, a type of tumour that occurs within the brainstem, making it almost impossible to remove surgically. Research published in Science Translational Medicine has used a type of molecule (antisense-ASO oligonucleotides) in mouse models of this tumour to slow tumour growth and prolong survival. The authors hope that the research will reach clinical trials and, in that case, the potential new treatment would be combined with others such as radiotherapy or immunotherapy with CAR-T cells.
An international group of researchers has conducted an epidemiological study to investigate the correlation between fine particulate matter (PM2.5) air pollution and certain types of lung cancer. The authors have confirmed their findings in animal models, according to research published in Nature.
A study published in the journal Cell shares the case of the "New York patient", a woman with leukaemia and HIV who identifies as "mixed race" and has been free of the virus since 2017. She would be the first woman to be cured of the virus after a bone marrow transplant and there are now four such cases, along with patients in Düsseldorf, Berlin and London. The method involves transplanting HIV-resistant stem cells, this time from umbilical cord blood.
Un estudio ha estimado las muertes por cáncer que se producirán en la Unión Europea y el Reino Unido en 2023. Comparándolas con las observadas en 2018, estiman que se reducirán en un 6,5 % en hombres y un 3,7 % en mujeres de forma global. Sin embargo, en España aumentará la mortalidad por cáncer de pulmón en mujeres. Los resultados se publican en la revista Annals of Oncology.
The Centre for the Coordination of Alerts and Health Emergencies (CCAES) reported yesterday that last February Germany reported two cases of dengue (one confirmed and one probable), along with four cases compatible with epidemiological links, in residents of Germany who had travelled to Ibiza during the incubation period. One of the potential vectors of dengue is the Aedes albopictus mosquito, which was first detected in Ibiza in 2014. According to the CCAES, the risk of new autochthonous cases appearing in Ibiza, "at this time of low vector activity, is considered low".
Every February 28 or 29, World Rare Disease Day is celebrated, an initiative that aims to raise awareness about rare diseases in order to improve access to diagnosis and treatment and achieve a better quality of life among those who suffer from them. Here are some frequently asked questions about the most important concepts, their current situation and the main complaints that affected individuals and families continue to have.