Spanish National Cancer Research Centre CNIO
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Head of the Metabolism and Cell Signalling Group at the CNIO
Researcher at the Centro Nacional de Investigaciones Oncológicas, president of the Commission of Personalised Medicine of the Spanish Association of Human Genetics and vice-president of the Spanish Society of Pharmacogenetics and Pharmacogenomics
Head of the Bioinformatics Unit at the National Cancer Research Center (CNIO)
Head of the Joint Cancer Immunotherapy Unit H12O/CNIO (Hospital Universitario 12 de Octubre/Centro Nacional de Investigaciones Oncológicas).
Group Leader. EMBO YIP. ERC investigator. Co-founder and Scientific Director of RENACER. Brain Metastasis Group. Molecular Oncology Programme, CNIO.
Head of the Cell Division and Cancer Group at the CNIO and visiting professor at the Dana Farber Cancer Institute at Harvard University (Boston)
CNIO Director
Junior Principal Investigator at the Spanish National Cancer Research Centre (CNIO)
Head of the Melanoma Group at the Spanish National Cancer Research Centre (CNIO)
Head of the Growth Factors, Nutrients and Cancer Group of the National Cancer Research Center (CNIO)
Approved therapies to treat various tumours using CAR-T cells are based on the modification of the patient's own lymphocytes in the laboratory, which delays their administration. A phase 1 clinical trial has used ready-made donor cells to treat patients with multiple myeloma. The results are published in the journal Nature Medicine.
Two preclinical studies published in the journal Science have introduced new bioengineered modifications to CAR-T cells in an attempt to make them more potent and safer in their anti-tumour action. These variations allow their activity to be enhanced only in the vicinity of the tumour or their actions to be regulated on demand.
The US companies Moderna and Merck (MSD outside the US and Canada) have announced this week the results of their phase 2b trials of their skin cancer therapy. The results were shared in a press release stating that the risk of recurrence or death is reduced by 44%.
A ketogenic diet, high in fat and low in carbohydrates, could increase platelet production and alleviate the low platelet counts caused by chemotherapy treatments. This is the finding of a small study published in the journal Science Translational Medicine.
A study published today in Science Advances describes the case of a person who in less than 40 years of life has developed twelve tumours, five of them malignant, due to inherited mutations in a gene. The research reveals that his immune system has naturally generated an altered inflammatory response that fights tumours. Understanding the mechanism will be useful to stimulate this type of response in other cases, according to the CNIO authors of the study.
The extraordinary plenary session of the Congress of Deputies today approved the reform of the Law on Science, Technology and Innovation. After being passed in the Lower House without any votes against it on 23 June, the bill was approved in the Senate on 20 July with an amendment referring to indefinite-term contracts, which was rejected today in Congress.
Glioblastoma is an aggressive type of cancer that arises in the brain or spinal cord. Researchers have identified a new drug that exploits DNA repair defects to selectively target tumours that are resistant to chemotherapy treatment with temozolomide. The research is published in Science.
A study published in Nature identifies a metabolite produced during exercise that can effectively reduce food intake and obesity in mice. It has also been found in humans.
"The level of alcohol consumption that does not harm health is zero," says a review of dozens of studies conducted in recent years on the effect of light drinking. The 20 or so authors of the paper, and other experts, insist that "alcohol is carcinogenic from the first drink". In their view, this message should be conveyed more clearly to the public.
Caloric restriction (substantially reducing food intake in a controlled way) prolongs longevity in many animal species. A new result in mice, published in Science, finds that this effect is greater if the animals only eat during the body's natural active phase.