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Reaction to review examining the relationship between PFAS exposure and liver damage

A review of studies in rodents and humans examines the relationship between exposure to perfluoroalkyl substances (PFAS) and liver damage.

03/05/2022 - 12:15 CEST
Expert reactions

Miquel Porta - PFAS EN

Miquel Porta

Professor of Public Health at the Hospital del Mar Medical Research Institute and author of the book Epidemiología cercana

Science Media Centre Spain

The study is a meta-analysis in rodents and also in humans.

The results integrate mechanistic and observational knowledge in humans. They are valid and highly relevant at scientific, clinical, social and public health levels.

I wonder which public health authorities are taking action to prevent and reduce human contamination by PFASs.

I also think it is very important that clinicians (e.g. hepatologists, internists, primary care physicians) and researchers (clinical and laboratory) are aware of the results of studies like this one, so that they consider the environmental causes of pathologies like non-alcoholic steatohepatitis, which are very frequent, epidemic.

They should also think about the environmental causes of frequent alterations in enzymes and other biomarkers of liver damage / liver function, such as alanine aminotransferase, aspartate aminotransferase and gamma-glutamyl transferase.

There is no scientific or medical justification for clinical research and practice to be so detached from environmental factors such as PFASs.

The author has not responded to our request to declare conflicts of interest
Exposure to per- and Polyfluoroalkyl Substances and Markers of Liver Injury: A Systematic Review and Meta-Analysis
  • Research article
  • Peer reviewed
  • People
  • Animals
Environmental Health Perspectives
Study types:
  • Research article
  • Peer reviewed
  • People
  • Animals
  • Meta-analysis
  • Systematic review
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