A review of studies in rodents and humans examines the relationship between exposure to perfluoroalkyl substances (PFAS) and liver damage.
The study is a meta-analysis in rodents and also in humans.
The results integrate mechanistic and observational knowledge in humans. They are valid and highly relevant at scientific, clinical, social and public health levels.
I wonder which public health authorities are taking action to prevent and reduce human contamination by PFASs.
I also think it is very important that clinicians (e.g. hepatologists, internists, primary care physicians) and researchers (clinical and laboratory) are aware of the results of studies like this one, so that they consider the environmental causes of pathologies like non-alcoholic steatohepatitis, which are very frequent, epidemic.
They should also think about the environmental causes of frequent alterations in enzymes and other biomarkers of liver damage / liver function, such as alanine aminotransferase, aspartate aminotransferase and gamma-glutamyl transferase.
There is no scientific or medical justification for clinical research and practice to be so detached from environmental factors such as PFASs.
- Research article
- Peer reviewed