Autonomous University of Barcelona

The Karolinska Institute has awarded the Nobel Prize in Medicine or Physiology to Karl Deisseroth, Peter Hegemann, and Georg Nagel for their discoveries regarding light-activated ion channels and optogenetics. This method, which makes it possible to activate or deactivate individual neurons in a living brain, “is currently used in laboratories around the world to unravel the mysteries of the brain,” the institute announced. 

A team of Spanish researchers has investigated the early stages of metastatic cells taking hold in target organs and has discovered that there is a transitional stage during which these ‘metastatic seeds’ are particularly vulnerable. They have also demonstrated in mice and in human samples that these micrometastases can be eliminated using three drugs, two of which are already approved for other indications. The study is published in the journal Cancer Cell.

A study published in Science Advances suggests that the use of betel nut as a drug has older origins than previously thought. Bone remains from two pre-agricultural hunter-gatherers — dated between 25,000 and 16,000 years ago — from Sulawesi (Indonesia) show dental pathology associated with the consumption of these whole nuts. Considered one of the world’s oldest known drugs, when consumed, this nut releases arecoline, the plant’s main neuroactive alkaloid. According to the research, it is possible that the hunters-gatherers’ sole motivation for using it was not merely as a drug, but also for its analgesic and digestive properties.

Various studies have shown that smokers have a lower risk of developing Parkinson’s disease, but the causes remain unknown. A study has analysed the role played by carbon monoxide — a toxic gas produced by the combustion of tobacco — in this association. To this end, the team conducted a twelve-year follow-up study of more than half a million adults in China. The results show that regular smoking was associated with an increased risk of lung cancer, ischaemic heart disease, stroke and all-cause mortality, but with a lower risk of Parkinson’s disease. Most strikingly, amongst people who had never smoked, higher levels of exhaled carbon monoxide—which the authors measured—were associated with a lower risk of Parkinson’s disease. According to the study, published in JAMA Neurology, these findings demonstrate a possible protective role of carbon monoxide in the disease, rather than smoking itself.

A team from the UK and the Netherlands has estimated the environmental cost attributed to the actions of the top 10% of spenders—generally the wealthiest—both globally and in the richest country on each continent. Globally, they are responsible for damages worth between US$1.7 trillion and US$5.7 trillion. These figures exceed the funding needed to meet the 2035 climate finance target agreed upon at COP30—US$993 billion—and to cover the funding needed to halt biodiversity loss by 2030—US$657 billion. The study is published in Communications Sustainability, a journal of the Nature group. 

An article published in Brain Health proposes using the concept of the ‘criticome’ to refer to the sensory, motor, social, cultural and environmental information recorded from pregnancy up to the age of 25, which is the period of greatest brain plasticity. According to the authors, this concept reframes autism, schizophrenia and depression as developmental disorders rather than purely synaptic disorders. Besides, they say this approach would have implications for educational policy, mental health care and screen use, amongst other issues.

A newly discovered ape fossil in northern Egypt suggests that the closest ancestors of modern apes may have originated in North Africa, outside the East African regions that have traditionally been studied. Dating back between 17 and 18 million years, the new species —Masripithecus moghraensis — represents the closest known hominid relative to the lineage that ultimately gave rise to all living apes, including humans. The study is published today in the journal Science. 

The economic costs of CO₂ emissions can be calculated in three ways: through the historical damages resulting from past emissions; through the expected future damages caused by those past emissions; and through the expected future damages from current or future emissions. A study published in Nature concludes that the future economic costs associated with past emissions could be at least ten times higher than the costs already incurred from those same emissions. The authors estimate that one tonne of CO₂ emitted in 1990 caused $180 (around €155) in global damages up to 2020, but will generate an additional $1,840 (nearly €1,590) by 2100. The analysis covers countries, high-net-worth individuals and major companies, as well as behavioural patterns, including taking an additional long-haul flight each year or choosing a non-vegetarian diet.

A study published in Nature suggests that a brain network that controls the execution of actions (SCAN), which was described in 2023, plays an important role in Parkinson's disease. Focusing treatments—such as transcranial stimulation—on the SCAN rather than other brain regions associated with movement could improve their effectiveness, according to the research.

The American Psychiatric Association has unveiled the new features of the forthcoming Diagnostic and Statistical Manual of Mental Disorders (DSM) in five articles published in The American Journal of Psychiatry. Among the highlights are the proposed change of name — it will become the Diagnostic and Scientific Manual — and the intention for it to be more dynamic, incorporating biomarkers for diagnosis and integrating the socioeconomic, cultural and environmental determinants of health. According to the authors, the aim is to enable a more personalised and inclusive clinical practice, aligned with scientific rigour. The most recent update was published in 2022 with the DSM-5-TR, and specialists are currently unaware of the date of the next edition, as they reported during a briefing with journalists.