Autonomous University of Barcelona

The frequency and intensity of extreme heat events have increased in recent years, heightening the risks for those who work outdoors and indoors. Health risks include heatstroke, dehydration, kidney dysfunction and neurological disorders. These are some of the conclusions of a joint report by the World Health Organisation (WHO) and the World Meteorological Organisation (WMO), which estimates that worker productivity falls by between 2% and 3% for every degree above 20°C. The document proposes measures for governments, businesses and health authorities to mitigate the risks of extreme heat for these people.

An analysis published in the medical journal The BMJ points out that lifestyle changes recommended by doctors to people with obesity, focusing on calorie restriction and increased physical activity, have little effect on long-term weight loss, fail to significantly reduce cardiovascular risks and, yet, can lead to discrimination, stigmatisation and eating disorders. The authors also point out that weight alone is an inadequate measure of a person's health, as reflected in recent clinical guidelines, and propose a ‘health for all sizes’ approach with effective, patient-centred care.

So-called precision oncology involves the use of drugs that target specific molecular alterations in the tumour. These therapies are usually tested in clinical trials in adults and most have not been approved for use in children. An opinion article calls for these trials to be extended to children as well, given the difficulty of conducting such trials in children due to the small number of cases. According to the authors, who publish the text in the journal Trends in Cancer, given that children and adolescents tend to tolerate therapy better than older adults, ‘the time has come to consider age-agnostic approvals, i.e. approvals that include children and adults of any age’.

A new study sheds light on how the brain adjusts its ‘wiring’ during learning, concluding that different dendritic segments of the same neuron follow different rules for communicating through their connections - synapses. The findings challenge the idea that neurons follow a single learning strategy and offer a new perspective on how the brain learns and adapts its behaviour. The work, carried out in mice, is published in the journal Science.

Meeting in the city of Windoek (Namibia), the plenary of the IPBES - Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services - has ratified two new reports: the Nexus Assessment and the Transformative Change Assessment. Three of their authors explained the main findings and the changes they propose at a briefing organised by SMC Spain.

A team of researchers has analysed the evolution of 4,550 people aged 25 to 65 diagnosed with type 2 diabetes who had been studied for 30 years in the UK. They found that those diagnosed before the age of 40 had a risk of dying almost four times higher than in the general population. If diagnosed later, the risk was 1.5 times higher. The authors publish their findings in the journal The Lancet Diabetes & Endocrinology.

A report by the Lancet Commission on Self-Harm highlights that at least 14 million episodes of self-harm occur each year - particularly among young people and in low- and middle-income countries. The paper argues that their impact has been neglected by governments globally and sets out a series of recommendations to reduce their incidence. 

Newborns with Down syndrome, as they grow, face a higher risk of developing leukemia compared to those without the syndrome. An international team has sequenced the genes of more than 1.1 million cells from fetuses with and without Down syndrome, and it has discovered that the extra chromosome 21 they have alters the way DNA is packaged inside cells. According to the authors, whose research is published in Nature, this difference affects the regulation of certain genes and may contribute to the development of leukemia.

An international team of researchers has analyzed various data sources and scientific literature and identified 3,601 chemical substances in human samples such as blood, urine or breast milk that are known to be in contact with food, for example, because they are used in packaging. According to the authors of the study, “this work shows that food contact materials are not completely safe, even if they comply with regulations, because they transfer known substances to food". The research is published in the Journal of Exposure Science and Environmental Epidemiology.

A study describes changes in a woman's brain during and after pregnancy, including a ‘pronounced’ decrease in grey matter volume and cortical thickness, and an increase in ventricular volume and cerebrospinal fluid. Some of the changes are maintained in the postpartum period; others reverse within months. The team performed 26 MRI scans and blood tests on one mother, from pre-conception until two years postpartum, and publish the results in Nature Neurology.