A multidisciplinary study involving several Spanish research groups has preclinically tested a new type of immunotherapy for multiple myeloma. Instead of modifying T cells to attack the tumour directly, as CAR-T cells do, they have managed to make them secrete bispecific antibodies, which bind to the tumour on one side and to other T cells on the other, attracting them to the tumour. According to the authors, this cell therapy was more effective than traditional CAR-Ts and could generate less resistance. The results are published in the journal Science Translational Medicine. 

A study has analysed more than 100 environmental factors and their impact on the immune response. After studying about a thousand volunteers, its conclusions are that smoking is the factor that causes the most alterations in defences. While some changes are transient, others may remain for years after quitting. The results are published in the journal Nature.

In a recent publication, we discovered that efforts to monitor genetic diversity in Europe are incomplete and need to be extended to account for potential climate change impacts on species of conservation interest.

One in five species included in the list of the Convention on the Conservation of Migratory Species of Wild Animals (CMS, to which Spain is a party) is in danger of extinction. These are data from the first global monitoring report on these species published by the World Conservation Monitoring Centre, a branch of the United Nations Environment Programme (UNEP). This figure rises to 97% for fish species. The authors warn that the situation has deteriorated in recent decades due to "intense levels of anthropogenic pressure". The presentation of the report coincides with the start of the COP on the conservation of these species in Uzbekistan (COP14).

A team of researchers has developed a device that would allow individuals with amputations to perceive and respond to temperature by providing thermal information from the tip of the prosthetic finger to the amputee's stump. The device, called "MiniTouch," featured in the journal Med, can be integrated into commercially available prosthetic limbs and does not require surgery. The authors demonstrate that, thanks to the thermosensitive prosthetic hand, a 57-year-old male with below-elbow amputation was able to distinguish and manually classify objects of different temperatures and perceive bodily contact with other humans.

Drugs to treat erectile dysfunction may be associated with a reduced risk of Alzheimer's disease, according to an observational study of nearly 270,000 men, published in Neurology. The research does not prove that these drugs reduce the risk of Alzheimer's, but only shows an association.

Two teams of researchers have separately described a population of memory lymphocytes that may be responsible for the persistence of allergies over time. The work has analysed responses to allergens such as those present in peanuts, dust and birch. According to the authors, whose research is published in Science Translational Medicine, these cells could serve as a target for the treatment of various types of allergies.

A study in South Korea followed more than 160,000 women for more than eight years and concluded that infection with different strains of human papillomavirus is associated with a fourfold increase in the relative risk of dying from cardiovascular causes. According to the authors, "it could be that the virus causes inflammation in the blood vessels, contributing to blockage and damage to the arteries". The findings are published in the European Heart Journal.

The European Centre for Disease Prevention and Control (ECDC) reported that on January 29th, Spanish authorities notified a possible case of human infection with swine flu virus A(H1N1)v in a worker from a Catalan pig farm. After being diagnosed with bronchitis, subsequent laboratory analyses confirmed it as swine flu A(H1N1)v. The ECDC informs that the patient has fully recovered, and to date, no new cases have been detected among close contacts or among the worker's colleagues at the farm.

In 2010, nearly 1,000 sub-basins around the world were facing water shortages. But when considering not only water quantity, but also water quality, this figure rises to more than 2,500, according to a study published in Nature Communications. By 2050, the authors estimate that up to a third of sub-basins will face severe shortages of clean water, which could affect 3 billion people. Southern China, Europe, North America and Africa will be the most affected regions.