pediatrics

People who had a lower respiratory tract infection—such as bronchitis or pneumonia—before the age of two have twice the risk of premature death from respiratory disease in adulthood, according to a study published in The Lancet. The research is based on long-term data from over 3,500 people born from 1946 onwards in England, Scotland and Wales. According to the study, one in five premature deaths in this representative sample could be due to respiratory infections. The team adjusted their estimate by taking into account factors such as socioeconomic status in childhood and smoking in adulthood.  

A study in California has found that 41% of deaths in the first year of life are due to genetic diseases. This percentage is higher than previously thought. According to the authors, strategies to improve neonatal genetic diagnosis may reduce infant mortality, as this diagnosis is sometimes missed or arrives late. The research is published in JAMA Network Open.

A series on breastfeeding published today in The Lancet highlights the economic and political power of formula companies, examines their marketing practices and the impact this has on the health of mothers and children.

Researchers have analysed the efficacy of the meningococcal serogroup B vaccine (4CMenB, Bexsero) in more than 1,500 children under five years of age in Spain. The research, published in the New England Journal of Medicine, shows that full vaccination was effective in preventing invasive meningococcal disease of both serogroup B and other serogroups in this child population. The vaccine, which had been sold privately in Spain since 2015, had already been included by several autonomous communities in their vaccination schedules. Last December, the Interterritorial Council of the National Health System (CISNS) approved its inclusion in the vaccination schedule for the whole of Spain.

Bubble boy syndrome is a very serious condition caused by combined immunodeficiency. It is sometimes caused by certain mutations in the gene that codes for the Artemis protein. A phase I-II clinical trial has tested a gene therapy that adds a correct copy of the gene. The results are published in the journal NEJM.

The World Health Organisation (WHO) has issued a statement recommending skin-to-skin contact immediately after birth to improve the survival of premature and low birth weight babies. Until now, in clinical practice it was common for the first phase after birth to take place in the incubator.

The European Medicines Agency (EMA) has recommended marketing authorisation in the European Union for Beyfortus (nirsevimab) to prevent respiratory syncytial virus (RSV) lower respiratory tract disease in babies and infants. The agency recommends it during its first RSV season. The European Commission now has to decide on its marketing authorisation across the EU.

Según datos de la OMS y UNICEF, 25 millones de niños no han recibido sus vacunas contra la difteria, el tétanos y la tosferina (DTP) a nivel global. Se trata de la mayor caída continuada en cobertura vacunal en casi treinta años.

After the acute phase of SARS-CoV-2 infection, children may develop long covid-19 symptoms. Research published in The Lancet Child and Adolescent Health examines the prevalence of these symptoms, quality of life, number of sick days, absences from school, and psychological and social outcomes in children aged 0-14 years who had been infected with SARS-CoV-2.