University of Alcalá

Amino acids are the building blocks of proteins. These are known as the building blocks of life, but they cannot replicate themselves. To do so, they need the instructions provided by RNA. How this relationship began is still a mystery. Now, a British team has shown how it could have started from relatively simple conditions. According to the researchers, who published their findings in the journal Nature, ‘understanding the origin of protein synthesis is fundamental to understanding where life comes from.’

Analysis of data from a mobile health app covering more than 5,000 people in 1,609 cities in the United States reveals that moving from a less walkable area to a more walkable area leads to an increase in the number of steps taken per day, and vice versa. Walkability was measured using the Walk Score, an index based on parameters such as proximity to services, block length and intersection density. According to the authors, the results can serve as a guide for urban design policies that improve public health. The study is published in Nature.

Ahead of the anticipated conclusion of a United Nations global treaty on plastics, a group of international experts calls for greater attention to health effects when addressing plastic pollution. The work, published in The Lancet, reviews current evidence on how plastics—including microplastics and plastic chemicals—affect health, and announces the launch of a new project to monitor these effects.

The research article A bacterium that can grow by using arsenic instead of phosphorus was one of the big science stories because it discussed the possibility of arsenic-based life. However, it has been the subject of criticism until now. After nearly 15 years of debate and failed attempts by other groups to replicate the findings, Science has now decided to retract the article, despite finding no evidence of fraud or misconduct on the part of the authors, who disagree with the decision.

An analysis published in the medical journal The BMJ points out that lifestyle changes recommended by doctors to people with obesity, focusing on calorie restriction and increased physical activity, have little effect on long-term weight loss, fail to significantly reduce cardiovascular risks and, yet, can lead to discrimination, stigmatisation and eating disorders. The authors also point out that weight alone is an inadequate measure of a person's health, as reflected in recent clinical guidelines, and propose a ‘health for all sizes’ approach with effective, patient-centred care.

The U.S. Presidential Malaria Initiative is a project that has been in place since 2005 to reduce malaria cases and deaths in Africa. The Donald Trump administration has halted some of its services and questioned its continuity. Now, a team has analyzed the possible consequences in 27 of the most affected countries on the continent. According to their estimates, some 104,000 deaths and around 13.6 million cases would be avoided if full funding were maintained. The results are published in The Lancet.  

A team from the United States has analysed data on modes of transport in more than 11,500 cities in 121 countries around the world, including Spain, representing 41% of the world's population. In addition to studying the factors that most influence the proportion of journeys made on foot or by bicycle, they estimate that if each city analysed increased the extent of its cycling network to the level of Copenhagen (Denmark), private vehicle emissions would be reduced by 6% and the public health benefits would be equivalent to around £37 billion. The results are published in the journal PNAS.

Gonorrhoea is the second most common sexually transmitted disease in the world, with 80 million cases each year. There is no effective vaccine, and the bacteria responsible are becoming resistant to common antibiotics. Some studies have suggested that the meningococcal B vaccine, a unrelated bacterium, may offer partial protection against gonorrhoea. Now, an Italian team has identified 17 antibodies that could explain this cross-immunity, which, according to the authors, could be used to develop treatments and vaccines. The results are published in the journal Science Translational Medicine.

A study has identified and tested 22 compounds that inhibit the development of Plasmodium falciparum—one of the parasites that cause malaria—in the mosquitoes that transmit it. The most effective molecule killed 100% of the parasites present within six minutes, even in insecticide-resistant mosquitoes, according to the study published in Nature. These compounds could be used to treat bed nets.

Research published in Science Advances concludes that the level of microplastics in the environment could be three times higher in 2060 than in 2019, even if one of the two more ambitious policy scenarios proposed by the OECD to reduce plastics is implemented.