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An international team has analysed gender representation in more than 1,000 clinical trials on cardiovascular disease between 2017 and 2023, involving more than one million people. Although female participation has increased, especially in areas such as obesity and heart failure, women continue to be underrepresented overall compared to men. The results, presented at the European Society of Cardiology (ESC) Congress held in Madrid from 29 August to 1 September, are published in JAMA Network Open.

For women diagnosed with early-stage breast cancer, the long-term risk of developing a second primary cancer is low, around 2–3 per cent higher than that of women in the general population. This is one of the conclusions of a study published by The BMJ, which analysed data from nearly half a million women diagnosed in England between 1993 and 2016 with early-stage invasive breast cancer who underwent surgery. During a follow-up period of up to 20 years, around 65,000 women developed a second primary cancer, but the absolute excess risk compared to the risks in the general population was small.

So-called ‘supercell thunderstorms’ — incredibly intense phenomena that bring hurricane-force winds, hail, torrential rain and often tornadoes — will become more frequent in Europe as the Earth continues to warm. This is the conclusion of a study published in Science Advances, which indicates that the increase could reach 11% in a scenario where temperatures rise by 3°C.

Until now, perceived well-being followed a U-shaped curve depending on age, declining – due to worry, stress or depression – until people reached middle age, around 50, and then rebounding into old age. With malaise, the U is inverted and we talk about the ‘unhappiness curve’, shaped like a hump. Now, research published in PLOS One with data from the US and the UK claims that this age-related malaise is declining and that there is no longer such a hump. The reason for the change is said to be the deterioration of mental health among young people, especially those under 25. The study also includes data from 44 countries between 2020 and 2025, including Spain, and confirms that the malaise no longer takes the form of a hump, but decreases with age.

An international team with Spanish participation has analyzed data from more than 500,000 people and found a link between digestive disorders such as colitis, gastritis, esophagitis, or functional bowel disorders and an increased risk of developing Alzheimer's and Parkinson's diseases. According to the researchers, who published their findings in the journal Science Advances, “this effort sheds light on the interaction between factors involved in the gut-brain axis and opens avenues for targeted treatment and early diagnosis.”

The upper part of the human pelvis, the ilium, underwent two major structural changes during evolution that enabled humans to walk on two legs. One was the formation of cartilage and the second was the process of bone formation. New research identifies differences in the way bone cells are deposited on cartilage in the human ilium, compared to other primates and human long bones. The study, published in Nature, lays the genetic and evolutionary foundations for bipedalism, according to the authors.

Amino acids are the building blocks of proteins. These are known as the building blocks of life, but they cannot replicate themselves. To do so, they need the instructions provided by RNA. How this relationship began is still a mystery. Now, a British team has shown how it could have started from relatively simple conditions. According to the researchers, who published their findings in the journal Nature, ‘understanding the origin of protein synthesis is fundamental to understanding where life comes from.’

A team in China has transplanted a pig lung, genetically modified using CRISPR, into a brain-dead human. According to the researchers, this is the first time a lung transplant of this kind has been performed. The organ remained viable for the nine days of the study, although it showed some signs of damage and immune rejection. The results are published in the journal Nature Medicine.

The frequency and intensity of extreme heat events have increased in recent years, heightening the risks for those who work outdoors and indoors. Health risks include heatstroke, dehydration, kidney dysfunction and neurological disorders. These are some of the conclusions of a joint report by the World Health Organisation (WHO) and the World Meteorological Organisation (WMO), which estimates that worker productivity falls by between 2% and 3% for every degree above 20°C. The document proposes measures for governments, businesses and health authorities to mitigate the risks of extreme heat for these people.

Light pollution is causing birds to sing more, prolonging their vocalisations by an average of 50 minutes, according to a study published in Science. The study, which analyses more than 580 species of diurnal birds, shows that those most exposed to light, either because they have large eyes or open nests, are the most affected by this phenomenon. The authors analysed more than 60 million vocalisations from the BirdWeather citizen science project. ‘The machine learning algorithm allows us to analyse audio recordings 24 hours a day, seven days a week, which would otherwise take a lifetime to listen to,’ says Breant Pease, one of the authors.