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A US study analysing data from nearly 700,000 people concluded that those with a history of herpes simplex virus (HSV-1) infections were at greater risk of developing Alzheimer's disease. The study, published in BMJ Open, also showed that patients with this virus who used anti-herpes treatments were less likely to develop the disease.
The Member States of the World Health Organisation (WHO), meeting on Monday in Committee A of the World Health Assembly, approved a resolution calling for the adoption of a historic global pact to make the world safer from future pandemics. On Tuesday, the Assembly, in plenary session, adopted by consensus the world's first agreement on pandemics.
In online debates, Large Language Models (LLMs, i.e. Artificial Intelligence systems such as ChatGPT) are more persuasive than humans when they can personalise their arguments based on their opponents’ characteristics, says a study published in Nature Human Behaviour which analysed GPT-4. The authors urge researchers and online platforms to ‘seriously consider the threat posed by LLMs fuelling division, spreading malicious propaganda and developing adequate countermeasures'.
New gene editing technologies, such as gene drive tools, open the door to deliberately extinguishing species. An analysis article published in Science examines the ethical implications of this possibility based on three specific examples: the eradication of rats, the cattle barren worm, and the Anopheles gambiae mosquito, which transmits malaria. The analysis attempts to answer the question: ‘When and under what circumstances could the intentional eradication of a species be justified?".
A team from the Children's Hospital of Philadelphia and Penn Medicine (United States) has successfully treated a baby diagnosed with a rare genetic disorder using personalised CRISPR gene editing therapy. The baby, known only by the initials KJ, was born with a rare metabolic disease known as severe carbamoyl phosphate synthetase 1 (CPS1) deficiency. After spending the first months of his life in hospital on a very restrictive diet, KJ received the first dose of his tailored therapy in February 2025, between six and seven months of age. The treatment, which is being used for the first time for this type of disorder, was administered safely, and the baby is now growing well and improving. The case is detailed in a study published by The New England Journal of Medicine (NEJM).
Research involving more than 200 patients with depression, whose symptoms had not improved after NHS talk therapy shows that those who took part in eight group sessions of mindfulness-based cognitive therapy saw their depressive symptoms reduced, compared with those who received treatment as usual. The study is published in The Lancet Psychiatry.
Narcolepsy type 1 is a sleep disorder characterised by excessive daytime sleepiness and cataplexy - sudden loss of muscle tone. Existing treatments are based on palliation of symptoms, with moderate success. Now, an international phase 2 clinical trial, involving CEU San Pablo University and other Spanish centres, published in the journal NEJM, shows the results of a new drug targeting the cause of the disorder. Overall, the benefits appear superior and no serious adverse effects were observed. According to the authors, ‘the results are promising’ and represent ‘a very significant impact on the quality of life of these patients’.
According to the results of a phase 2 trial, an oral norovirus vaccine generated a strong mucosal immune response and even reduced viral shedding in vaccinated volunteers. Signs of the vaccine's efficacy support its potential to address the lack of safe and reliable vaccines against this virus, which is a major cause of gastrointestinal infections worldwide. The results were published today in the journal Science Translational Medicine.
Research analysing 53 samples of human breast milk found that silica and metal nanoparticles were present in 42 of them. The study, published in PNAS, identified the mechanisms of nanoparticle infiltration from oral or respiratory exposure into blood vessels and subsequent accumulation in breast milk.
A migraine treatment drug, ubrogepant, also reduces common non-headache symptoms that occur in the hours before a migraine, according to the results of a large phase III clinical trial published in Nature Medicine. The results suggest that this could be the first acute treatment for symptoms that occur before migraine and have a significant impact on daily life, such as dizziness, sensitivity to light and noise, and neck pain.