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Although outbreaks of H5N1 avian influenza have reached record numbers in recent years, human infections remain anecdotal. A study published today in Nature identifies a protein responsible for inhibiting the replication of this virus in humans, while 'human' flus are able to evade it. The authors propose that this protein with antiviral activity evolved in primates and consider that resistance or sensitivity to it should be taken into account when assessing the zoonotic potential of avian influenza viruses.

Berna Sozen's lab at Yale University has announced a new milestone in the competition to create synthetic embryos: their human pluripotent stem cells self-organise into structures that mimic embryonic development on days 9-14 after fertilisation and include extra-embryonic tissues. Their achievement is published in Nature at the same time as another similar study, that of Magdalena Zernicka-Goetz, who a fortnight ago previewed her stem cell-derived human embryo model to The Guardian, sparking a controversy with Jacob Hanna, author of a preprint showing that she had achieved true synthetic embryos. 

From May to August 2022, 157,580 deaths were recorded, 20.5% more than in the same months of 2019, before covid. This increase in mortality was mainly among people aged 75 years and older. Of the causes of death directly related to the heat, heat stroke and dehydration stood out. These are some of the provisional data published by the National Statistics Institute (INE) in relation to deaths in 2022. Covid-19 was the most frequent cause of death, with 31,559 people dying, 20% less than in 2021.

We compared semen analyses of 45 patients before and after mild covid-19 infection. We found a significant decrease in sperm volume, sperm concentration, total and progressive motility and vitality after infection, and that these effects may be long-term.

An analysis of data published in the journal General Psychiatry with more than 66,000 diagnoses of gender dysphoria, mostly made in the United States, concludes that prevalence increased between 2017 and 2021, and that the median age decreased over the same period from 31 to 26 years.

A research team describes in Nature the presence outside the solar system of CH3+, a cation that could react with other molecules to form complex organic molecules. Its role in interstellar organic chemistry was described decades ago, but until now it had not been observed outside the solar system. The team, which includes co-authors from the CSIC's Institute of Fundamental Physics and the National Astronomical Observatory in Madrid, based their work on observations from James Webb Telescope.

If effective strategies are not developed, more than 1.3 billion people will be living with diabetes by 2050, some 800 million more than today. This is according to the lead study in a set of papers published in The Lancet and The Lancet Diabetes & Endocrinology. In addition, 75% of these people will live in low- and middle-income countries, which is largely due to "structural racism and inequality", according to the editorial accompanying the studies.

This week, Japan began testing a new facility designed to discharge treated wastewater from the Fukushima Daiichi nuclear power plant into the Pacific. The water has been used to cool the melted reactor. After filling more than 1,000 tanks, the storage should reach full capacity early next year.

A commentary published last Friday in the journal Molecular Psychiatry, signed by more than 30 researchers, challenges the conclusions of the systematic review published in the same journal in July 2022, in which the authors concluded that there was no evidence that low serotonin levels cause depression. The researchers in the new paper blame the earlier study for flaws in methodology, among other weaknesses.

Results of the first phase of a project to develop an artificial placenta in an animal model, to help extremely premature babies (born at 6 months gestation or less), were presented to the press today. The project is led by BCNatal, a fetal medicine research centre in Barcelona, with funding from the "la Caixa" Foundation, which has renewed its support for the second phase of the project.