The restriction of sugar during the first 1,000 days of life, starting from gestation, may protect against diabetes and hypertension in adulthood, according to a study published in Science. The research uses data from sugar rationing implemented in the United Kingdom after World War II. The findings highlight the long-term benefits of reduced sugar intake during early development.

A team of researchers led by the Center for Genomic Regulation in Barcelona has mapped the human spliceosome for the first time. This complex and partially unknown cellular machinery is responsible for cutting and splicing the RNA fragments encoded by genes in different ways, making it possible to obtain a wide variety of proteins from the same sequence. Its alteration is related to processes such as cancer, neurodegenerative processes or various rare diseases. According to the researchers, who publish the results in the journal Science, “by knowing exactly what each part does, we can find completely new angles to address a broad spectrum of diseases”.

The HTAN (Human Tumor Atlas Network) consortium is simultaneously publishing 11 papers in different journals of the Nature group. These include analyses of the architecture of tumors and their environment in more than 2,000 patients and twenty different locations, which will make it possible to study how they start and evolve. Among the novelties found are new clues about the development of metastasis and resistance to treatments, and the finding that colorectal cancer can arise from multiple cells with different mutations that act collectively, instead of from a single initial clone as previously thought.

The devastating effects caused by the DANA over the peninsula and the Balearic Islands in large parts of the Mediterranean area, especially in the Valencian Community and some regions of Andalusia, are a wake-up call on the relationship between these extreme events and climate change.  

A team of researchers from the United Kingdom has conducted a phase 2/3 clinical trial in people with a psychotic disorder to study the efficacy of interaction with a digital avatar in alleviating the discomfort generated by hearing voices. After analyzing it in 345 people, they conclude that it can reduce the frequency of occurrence at 16 and 28 weeks. The discomfort provoked is reduced at 16 weeks, but not at 28 weeks. The team publishes the results in the journal Nature Medicine.

The development of generative artificial intelligence, and in particular of large language models, could generate between 1.2 and 5 million tonnes of accumulated electronic waste between 2020 and 2030, according to a study published in Nature Computational Science. The study estimates the mass of waste generated by hardware elements such as processing units, storage units and power supply systems.

According to a Lancet Public Health commission on commercial gambling, stricter regulations are needed on a global scale to reduce its impact on health and wellbeing worldwide. The authors argue that the harms caused by gambling are a threat to public health, exacerbated by the rapid expansion and digital transformation of the industry. These harms include physical and mental health problems, increased risk of suicide, gender-based violence and financial problems.

Exposure to agrochemicals, even in doses too low to kill insects, causes significant damage to their behavior, development and reproduction, which is aggravated when the temperature rises, according to a study published in Science. The research analyzes the effects of 1,024 molecules - insecticides, herbicides, fungicides, plant growth inhibitors - on the fruit fly Drosophila melanogaster and on other insects.

Early results from a study of newborn screening methods show that DNA analysis detects many more serious preventable or treatable diseases than standard newborn screening. The study, published today in the journal JAMA, is one of the first large-scale studies in the world to use genome sequencing as a method of newborn screening and is the first to publish preliminary results. 

An international team with Spanish participation has analysed which day of the week has the highest risk of suicide mortality, and it is Monday. The research, published in The BMJ, includes more than 1,700,000 suicide cases registered in 26 countries - including Spain - from 1971 to 2019. The data also show a sharp increase in the risk of suicide on New Year's Day in most of the countries analysed. Taking these results into account, the authors propose that they should be used to define plans and awareness-raising campaigns.