The New England Journal of Medicine reports the publication of data from a clinical trial studying the drug Tofersen against a form of Amyotrophic Lateral Sclerosis (ALS) caused by mutations in the SOD1 gene, which accounts for 2% of sporadic ALS. Six months after treatment, some biomarkers of neuronal damage improved, but not the clinical condition of the patients. In an extension of the study, with no placebo group, a slowing of functional loss was observed, although the researchers acknowledge that there are limitations in interpreting this result.

The Plenary of the Senate has approved this afternoon the Proposition of Law for the recognition of legal personality to the Mar Menor lagoon and its basin. The law, which was approved in Congress last July, comes from a Popular Legislative Initiative signed by more than 600,000 people.

Researchers have analysed the presence of perfluoroalkyl and polyfluoroalkyl substances (PFASs) in 72 textile products purchased online in the US and Canada in 2020 and 2021. The results, published in the journal Environmental Science and Technology Letters, show high concentrations in school uniforms and higher concentrations in 100 % cotton as opposed to synthetics. 
 

International research on more than 3,000 tree and shrub species in 164 cities -including Barcelona, Valencia and Santa Cruz de Tenerife- reveals that up to two-thirds of urban tree species may already be experiencing climatic conditions that exceed their potential climate tolerance. The study is published in Nature Climate Change.

The European Medicines Agency (EMA) has recommended marketing authorisation in the European Union for Beyfortus (nirsevimab) to prevent respiratory syncytial virus (RSV) lower respiratory tract disease in babies and infants. The agency recommends it during its first RSV season. The European Commission now has to decide on its marketing authorisation across the EU.

Research published in Science proposes that an ancient moon of Saturn, which they have named Chrysalis (Chrysalis), may be responsible for Saturn's distinctive rings. According to the authors, the moon orbited around the gas giant for billions of years, but about 160 million years ago, it became unstable and moved too close to the planet, breaking apart under Saturn's tidal forces and forming the planet's rings. According to the research, Saturn's current tilt may also be related to the destruction of this moon.

A study published in the journal Nature Medicine has tested a therapy based on CAR-T cells - T lymphocytes modified in the laboratory - to treat five patients with systemic lupus erythematosus who did not respond to conventional treatments. According to the study, the symptoms subsided in all of them and the improvement was maintained throughout the duration of the study.

The Minister of Health, Carolina Darias, responded yesterday in the government control session in Congress to a parliamentary question that face masks will continue to be obligatory on public transport. According to Darias, the Alerts Committee justifies the measure "due to the high concentration of people in very small spaces, without adequate ventilation and on long journeys".

Using images taken by astronauts aboard the International Space Station, a team of researchers has designed a map showing the variation in the spectral composition of artificial lighting across Europe during 2012-2013 and 2014-2020. The results, published in the journal Science Advances, show a change associated with white LED lights and higher blue emissions, which the authors link to an increased risk of harmful effects on ecosystems.

Two researchers propose that the anti-diarrhoeal drug Loperamide could be a candidate for treating the main symptoms of autism spectrum disorder (ASD), such as difficulties in social interaction and communication. The research, published in the journal Frontiers in Pharmacology, has used a computer model that includes the proteins involved in ASD and has analysed how different drugs affect them.