SMC Spain

A team in the UK has developed the first laboratory-grown oesophagus in pigs that has been shown to safely replace an entire section of the organ and restore normal function, including swallowing, in a growing animal without the need for immunosuppression. The procedure, successfully carried out on eight pigs, involves removing cells from a donor organ, repopulating it with the recipient’s own cells and then implanting it. If this technology is adapted for use in humans, it could help in the treatment of newborns or children born with oesophageal atresia, a serious congenital malformation in which the oesophagus does not develop properly. The results are published in Nature Biotechnology.

The European Network of Transmission System Operators for Electricity (ENTSO-E) has published its final report on the blackout of 28 April 2025 that left mainland Spain and Portugal without power. The document, drawn up by a panel of 49 members, concludes that the blackout was caused by a combination of many interacting factors, including oscillations, deficiencies in voltage control, rapid power reductions and generator disconnections in Spain. These factors caused rapid voltage rises and cascading generation disconnections, leading to the blackout. At a press briefing, Damián Cortinas, Chair of the ENTSO-E Board of Directors, clarified: “The problem is not renewable energy, but voltage control, regardless of the type of generation”. He added: “This isn’t about high technology; it’s something we’ve been able to do for decades.” Experts have made recommendations to prevent similar situations in Europe, such as strengthening operational practices, improving monitoring of system behaviour, closer coordination and data sharing among electricity system operators. Furthermore, they have highlighted the need to adapt regulatory frameworks to implement these recommendations in line with the changing nature of the electricity system.

The German mathematician Gerd Faltings has won the Abel Prize, awarded by the Norwegian Academy of Science and Letters. Faltings, director emeritus of the Max Planck Institute for Mathematics, became a celebrity at the age of 29 for proving a conjecture that earned him the Fields Medal in 1986. His contributions have revolutionised arithmetic geometry, a branch of mathematics at the intersection of the two oldest: number theory and geometry.

Oral semaglutide is not effective in slowing the progression of the disease in patients with mild Alzheimer’s disease, according to the findings of the first large-scale, randomised phase 3 clinical trials published in The Lancet. In these trials, around 3,800 patients aged between 55 and 85 with a confirmed diagnosis and mild symptoms received up to 14 mg daily of oral semaglutide or a placebo. After two years, no significant difference in disease progression was observed. 

A study led by ISGlobal shows that European regions with higher levels of poverty and lower use of renewable energy face a greater risk of mortality from air pollution. The research, published in Nature Medicine, analysed 88.8 million deaths that occurred between 2003 and 2019 across 653 regions in 31 European countries, covering a population of 521 million people. Areas with higher GDP per capita, lower poverty rates, and longer life expectancy—mainly in northern and western Europe—showed lower mortality risks, while other regions, particularly in southern Europe, experienced up to double the associated risk.

Glutathione is considered an antioxidant due to its ability to repair cellular damage. The body produces it naturally, but it is also sold as an antioxidant supplement. A study in mice and human tissue, published in Nature, shows that cancer cells can break it down and use it as fuel—particularly the cysteine it contains—promoting tumour growth and survival. “Depriving tumours of extracellular glutathione or inhibiting its breakdown is potentially a viable therapeutic strategy for cancer patients,” the authors state.

A meta-analysis published in the journal JAMA Psychiatry showed that psychedelic-assisted therapy is no more effective against depression than traditional antidepressants in clinical trials. The research found differences in the use of double-blind methods—that is, when neither the participants nor the researchers know which treatment each group is receiving—which minimises subjective influences on the results. Double-blinding made a difference in the case of traditional drugs, but not in the case of psychedelics, confirming that these trials are, in practice, always open-label.

Physical inactivity driven by rising temperatures due to climate change could result in between 0.47 and 0.70 million additional premature deaths each year by 2050, according to projections from a new study published in The Lancet Global Health. The study analysed data on the relationship between temperature and physical inactivity across 156 countries between 2000 and 2022. Low- and middle-income countries, where access to air conditioning, the availability of shaded public infrastructure, and discretionary leisure time are limited, were the most affected. Spain is among the European countries expected to be most impacted.

A Japanese research team has identified the five nucleic bases (adenine, guanine, cytosine, thymine, and uracil)—which form the building blocks of DNA and RNA—in samples from the asteroid Ryugu, according to a study published in Nature Astronomy, which compares the composition of these samples with those from the asteroids Bennu and Orgueil. “The detection of various nucleic bases in asteroid and meteorite materials demonstrates their widespread presence throughout the solar system and reinforces the hypothesis that carbonaceous asteroids contributed to the prebiotic chemical inventory of the early Earth,” the authors write.

A team from Canada conducted a review and meta-analysis of 42 studies on self-harm in children and young people from 12 high-income countries between 2000 and 2024. According to the available data, corresponding to more than 200 million people under 25 years of age, there was an annual increase of 2.5% in self-reported self-harm and 3.5% in medical visits for self-harm, particularly among girls. The results are published in JAMA Pediatrics.