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Reaction: New synthetic antimicrobial developed that is effective against multidrug-resistant bacteria

Cresomycin, a new synthetic molecule, exhibits robust efficacy against multiple evolutionarily divergent forms of antimicrobial resistance (AMR), according to a study published today in Science. By structurally analyzing how antibiotics bind to ribosomes of various bacterial species, researchers developed a new antibiotic molecule that adopts the exact conformation necessary for ribosomal binding.

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Reaction: Study finds that wearing a school uniform is associated with less physical activity, especially in girls

Dressing in school uniform is associated with less physical activity in children, especially primary school girls, according to a study by the University of Cambridge (UK) published in the Journal of Sport and Health Science. The study analysed data on the physical activity levels of more than one million children aged 5-17 in 135 countries, including Spain, combined with an online survey.

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Reactions to a study on the use of e-cigarettes for smoking cessation

E-cigarettes combined with traditional therapies are more effective for smoking cessation than regular therapies alone, says a study conducted in Switzerland and published in the New England Journal of Medicine. The study involved two groups of about 600 participants each. At a 6-month control visit, 59.6% of the members of the e-cigarette group had not smoked tobacco in the previous week, compared to 38.5% in the control group.

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Reactions: New generation of T-cells against myeloma more effective in the lab than traditional CAR-Ts

A multidisciplinary study involving several Spanish research groups has preclinically tested a new type of immunotherapy for multiple myeloma. Instead of modifying T cells to attack the tumour directly, as CAR-T cells do, they have managed to make them secrete bispecific antibodies, which bind to the tumour on one side and to other T cells on the other, attracting them to the tumour. According to the authors, this cell therapy was more effective than traditional CAR-Ts and could generate less resistance. The results are published in the journal Science Translational Medicine. 

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Reactions: Ultrasounds increase sperm mobility by 266%

A team of researchers has demonstrated how a non-invasive ultrasound technique can increase the movement of human sperm in the laboratory by up to 266%. Using microfluidic droplets to evaluate individual sperm cells, which had not been done before, they found that ultrasound exposure induced movement in immobile sperm and improved swimming speeds in mobile ones. The work is published today in the journal Science Advances.

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Reactions: tobacco alters the immune response even in the long term

A study has analysed more than 100 environmental factors and their impact on the immune response. After studying about a thousand volunteers, its conclusions are that smoking is the factor that causes the most alterations in defences. While some changes are transient, others may remain for years after quitting. The results are published in the journal Nature.

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Reaction: UN report warns of migratory species decline

One in five species included in the list of the Convention on the Conservation of Migratory Species of Wild Animals (CMS, to which Spain is a party) is in danger of extinction. These are data from the first global monitoring report on these species published by the World Conservation Monitoring Centre, a branch of the United Nations Environment Programme (UNEP). This figure rises to 97% for fish species. The authors warn that the situation has deteriorated in recent decades due to "intense levels of anthropogenic pressure". The presentation of the report coincides with the start of the COP on the conservation of these species in Uzbekistan (COP14).

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Reaction: A temperature-sensitive prosthesis enhances the dexterity of amputated individuals

A team of researchers has developed a device that would allow individuals with amputations to perceive and respond to temperature by providing thermal information from the tip of the prosthetic finger to the amputee's stump. The device, called "MiniTouch," featured in the journal Med, can be integrated into commercially available prosthetic limbs and does not require surgery. The authors demonstrate that, thanks to the thermosensitive prosthetic hand, a 57-year-old male with below-elbow amputation was able to distinguish and manually classify objects of different temperatures and perceive bodily contact with other humans.

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Reactions: use of erectile dysfunction drugs associated with reduced risk of Alzheimer's in men

Drugs to treat erectile dysfunction may be associated with a reduced risk of Alzheimer's disease, according to an observational study of nearly 270,000 men, published in Neurology. The research does not prove that these drugs reduce the risk of Alzheimer's, but only shows an association.

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Reactions: two studies describe what may be the cells that sustain allergies over time

Two teams of researchers have separately described a population of memory lymphocytes that may be responsible for the persistence of allergies over time. The work has analysed responses to allergens such as those present in peanuts, dust and birch. According to the authors, whose research is published in Science Translational Medicine, these cells could serve as a target for the treatment of various types of allergies.

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