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Extensive warm-water coral reefs are facing widespread mortality and, unless global warming is reversed, will be lost, warns the report Global Tipping Points 2025. This is the first tipping point reached by the Earth system, the first in a series of tipping points that will cause ‘catastrophic’ damage—melting ice sheets, death of the Amazon rainforest, and collapse of vital ocean currents—unless humanity takes urgent action. The report also identifies positive tipping points that have been crossed on a global scale, for example in the area of solar energy and the adoption of electric vehicles.

According to the Global Burden of Disease study, and despite deep inequalities between countries, global life expectancy in 2023 was more than 20 years higher than in 1950. However, deaths among young people increased in some regions such as North America, Latin America—due mainly to suicide and drug use—and sub-Saharan Africa—mainly due to infectious diseases and injuries. Researchers also estimate that almost half of all deaths and disabilities could be prevented by modifying some of the main risk factors. The results are published in The Lancet and will be presented at the World Health Summit, being held in Berlin, Germany, from October 12 to 14.

A team conducted a meta-analysis of 100 studies, including more than 430,000 participants from 42 countries, to understand what factors drive energy-saving habits in homes. Their conclusions are that attitudes and moral sentiments are more influential than socioeconomic factors such as education and income level, which were barely related to energy-saving behaviors. According to the authors, who publish the results in the journal Cell Reports Sustainability, "the research suggests that exploring these deeper psychological factors is a way to get as many people as possible committed to saving energy."

The decline in egg quality has been considered the main cause of declining fertility with age. A new study published in Science shows that the cells and tissues surrounding the oocytes within the human ovary also play a crucial role. They identified 11 types of cells in the ovaries, including nervous system cells, that influence follicle development. In addition, they have discovered that oocytes are grouped into “pockets” within the ovary and that the density within these pockets declines over the years. 

A team from China has reported the results of the first liver transplant from a pig to a living human. Earlier this year, a procedure that served as a proof of concept was published, but it was performed on a brain-dead person. In this case, after modifying 10 genes in the porcine liver, an auxiliary transplant—not removing the entire organ—was performed on a 71-year-old patient with cirrhosis and liver cancer. It worked well for the first month, but on day 38, the graft had to be removed due to the development of complications, and the patient died on day 171. According to the researchers, who published the case in the Journal of Hepatology, this is "a fundamental step that demonstrates both the promise and the obstacles that remain to be overcome".

More than 54,600 children under the age of five in Gaza are in need of medical care for acute malnutrition, according to estimates from a study published in The Lancet, which shows that the prevalence of malnutrition decreases during a ceasefire and increases during Israeli blockades of access to food, water, or medicine. For example, after four months of severe aid restrictions—between September 2024 and January 2025—malnutrition increased from 8.8% to 14.3%, with a higher incidence in Rafah and among children between 24 and 59 months of age. The study, conducted by UNRWA, is based on data from more than 219,000 children between the ages of six and 59 months from various locations in the Gaza Strip, collected between January 2024 and August 2025.

On the internet, professional women are represented as younger—and therefore less experienced—than their male counterparts, even though this age difference does not correspond to actual data in the US, according to an article published in Nature. This study of gender and age stereotypes is based on an analysis of 1.4 million images on five platforms (Google, Wikipedia, IMDb, Flickr and YouTube), as well as nine large language models, such as ChatGPT, trained with texts from Reddit, Google News, Wikipedia and Twitter. 

The Royal Swedish Academy of Sciences has awarded the 2025 Nobel Prize in Chemistry to Susumu Kitagawa, Richard Robson, and Omar M. Yaghi for the development of molecular structures with large spaces through which gases and other chemicals can flow. These structures, called metal-organic frameworks, can be used to extract water from desert air, capture carbon dioxide, store toxic gases, or catalyze chemical reactions.

Tramadol is a painkiller prescribed for chronic pain and is considered safer than other opioids. A systematic review with meta-analysis that included 19 clinical trials with more than 6,500 people showed that, although it relieved pain, the effect was small and below what would be considered clinically effective. In addition, the analysis indicated that the drug is likely to increase serious adverse events, particularly cardiac events. Although an increased risk of some types of cancer was also detected, the authors question this effect due to the short follow-up period. ‘Given the limited analgesic benefits and increased risk of harm, the use of tramadol for chronic pain should be reconsidered, with preference given to safer alternatives and additional high-quality trials to clarify its risk-benefit profile,’ the researchers note in the study, published in BMJ Evidence Based Medicine.

The Royal Swedish Academy of Sciences has awarded the 2025 Nobel Prize in Physics to John Clarke, Michel H. Devoret, and John M. Martinis, who demonstrated both the quantum tunnelling effect and quantised energy levels in a system small enough to fit in the palm of your hand. These advances have served to develop the next generation of quantum technology, including quantum cryptography, quantum computers and quantum sensors.