University of the Basque Country (UPV-EHU)

Various studies have shown that exercise benefits the brain. Now, an international team has studied in mice how physical activity affects the brain and how these changes influence the effects of exercise. The research, published in Neuron, has shown that physical activity causes brain changes in a region of the hypothalamus involved in how the body uses energy and in regulating blood sugar. If these neurons were blocked immediately after exercise, the animals showed no improvement in endurance or metabolism with training. The authors suggest that activating these neurons may help the body recover faster, allowing other parts, such as the muscles, lungs, and heart, to adapt more quickly to more intense workouts.

Genetics accounts for approximately 55% of the variability of human lifespan, which is more than double previous estimates, according to research published in the journal Science. The analysis is based on mathematical models and data from twin registries in Denmark, Sweden, and the United States. According to the authors, this high heritability is similar to that of most other complex human traits and to the influence of genetics on the life expectancy of other species.

Several recent studies had concluded that the risk of gastric cancer doubled with the use of drugs such as omeprazole – proton pump inhibitors. A new study published in The BMJ states that there is no association between prolonged use of these drugs and the risk of gastric adenocarcinoma. The research used prospective data from registries in Denmark, Finland, Iceland, Norway, and Sweden between 1994 and 2020. The study included more than 17,000 patients with gastric adenocarcinoma (other than cardia cancer) who had been exposed to these drugs for more than one year.

A team from the United States has analyzed nearly twenty studies on melatonin use in children between the ages of 0 and 6 in different countries. Although it appears that melatonin can help improve sleep onset in children with neurological conditions such as autism spectrum disorders, the data indicate that in recent years there has been an increase in sales of these products without a clear understanding of their actual effectiveness and potential long-term consequences for typically developing young children. The results are published in JAMA Network Open. 

According to a study published in the journal JAMA Health Forum, the use of the benzodiazepine lorazepam by the character Victoria Ratliff in the series The White Lotus was associated in the United States with an increase in Google searches for this medication, including queries about how to obtain it online. The series generated 1.6 million more searches than usual over a 12-week period. Although the study reflects searches for information and not actual consumption, the abuse of anti-anxiety drugs is a fact: illegal sales of benzodiazepines have increased in the United States, and Spain leads the rankings in terms of consumption.

A team at Google DeepMind has developed AlphaProof, an artificial intelligence system that learns to find formal proofs by training on millions of self-formulated problems. According to the authors, the system “substantially improves upon previous-generation results on historical problems from mathematical competitions.” Specifically, in the 2024 International Mathematical Olympiad (IMO) for secondary school students, “this performance, achieved after several days of computation, resulted in a score equivalent to that of a silver medalist, marking the first time an AI system has achieved medal-level performance.” The results are published in the journal Nature.

In women suffering from post-traumatic stress disorder (PTSD) after experiencing sexual assault, the connectivity between two areas of the brain within the fronto-limbic system is altered, according to a study presented at the European College of Neuropsychopharmacology conference held in Amsterdam (Netherlands). The study, led by a researcher at Hospital Clínic in Barcelona, compared brain images of 40 women with PTSD following a recent sexual assault and 45 control cases. In 22 of these 40 women, communication between the amygdala—which helps process emotions such as fear—and the prefrontal cortex—which helps regulate those emotions—had almost completely disappeared.

Until now, perceived well-being followed a U-shaped curve depending on age, declining – due to worry, stress or depression – until people reached middle age, around 50, and then rebounding into old age. With malaise, the U is inverted and we talk about the ‘unhappiness curve’, shaped like a hump. Now, research published in PLOS One with data from the US and the UK claims that this age-related malaise is declining and that there is no longer such a hump. The reason for the change is said to be the deterioration of mental health among young people, especially those under 25. The study also includes data from 44 countries between 2020 and 2025, including Spain, and confirms that the malaise no longer takes the form of a hump, but decreases with age.

Research estimates that 15.6 million people born between 2008 and 2017 worldwide will develop gastric cancer at some point in their lives if current trends continue. In Spain, there would be 58,641 cases, or 1.24% of people in this age group. The team used data on gastric cancer from 185 countries in 2022 combined with mortality projections based on United Nations demographic data. The estimates, published in the journal Nature Medicine, show that 76% of cases could be attributed to Helicobacter pylori, a common bacterium found in the stomach.

A study evaluating the mathematical and linguistic performance of first- and second-year primary school students in France—more than 2.6 million children between 2018 and 2022—shows that the gender gap in mathematics appears within a few months of starting primary school. This gap increases with years of schooling, not with age, adds the research published in Nature.