22% of children worldwide have signs of disordered eating behaviours, a figure that rises to 30% for girls alone, according to an analysis published in JAMA Pediatrics led by researchers from the University of Castilla-La Mancha. The research brings together 32 previous studies that used the same diagnostic tool (the SCOFF questionnaire). It includes in total more than 60,000 children aged 6 to 18 in 16 countries. The article also states that the risk of disordered eating behaviour increases with age and Body Mass Index (BMI).  Disordered eating behaviours include behaviours such as ‘weight loss dieting, binge eating, self-induced vomiting, excessive exercise, and the use of laxatives or diuretics (although not to the level to warrant a clinical diagnosis of an eating disorder)’.

A virological and immunological follow-up confirms that a third patient has been cured of HIV nine years after receiving a bone marrow transplant for myeloid leukaemia, and four years after stopping his antiretroviral treatment. This case of the Düsseldorf patient, similar to two previously documented in Berlin and London, is detailed in a Nature Medicine publication by an international consortium coordinated by the IrsiCaixa AIDS Research Institute and the University Medical Center in Utrecht, the Netherlands. The patient was diagnosed with HIV in 2008 and in 2011 with leukaemia, for which he received the transplant in 2013.

A study estimates that household energy expenditure has increased by 62.6 to 112.9 % in 2022, following the Russia-Ukraine conflict. This represents an increase of 2.7 to 4.8 % of overall household expenditure. The analysis, published in Nature Energy, warns that this increase could push between 78 and 141 million people worldwide into extreme poverty.

A study in mice found that a molecule called TDI-11861 works as an oral male contraceptive, temporarily blocking sperm function. The paper, published in Nature Communications, presents the research as a step towards an on-demand male contraceptive drug: the user could take a birth control pill before sex and become fertile again the next day. Four co-authors of the study have founded a company in the US to develop such products. 

Research analysing data from more than 100,000 people in the UK followed for nearly a decade concludes that a higher intake of free sugars - added sugars or those naturally present in honey and fruit juice - is associated with an increased risk of cardiovascular disease. The study is published in BMC Medicine.

A study published in the journal PLOS Digital Health has analysed ChatGPT's performance on the US Medical Licensing Exams (USMLE). The results indicate that it could pass or come close to passing the exam.   

A study in California has found that 41% of deaths in the first year of life are due to genetic diseases. This percentage is higher than previously thought. According to the authors, strategies to improve neonatal genetic diagnosis may reduce infant mortality, as this diagnosis is sometimes missed or arrives late. The research is published in JAMA Network Open.

A phase 2 clinical trial has tested a type of immunotherapy based on oncolytic viruses in combination with chemotherapy for the treatment of triple-negative breast tumours. The results are published in the journal Nature Medicine.

People who have a parent, sibling, or step-sibling with major depression have a higher risk of major depression themselves, according to research based on data from 2.9 million people in Denmark. This risk increases with the number of affected relatives and when exposure to depression occurs in childhood and adolescence, but does not vary by sex or kinship, says the study published in JAMA Psychiatry.

Two studies have found changes in the microbiome of patients affected by chronic fatigue syndrome. In particular, they have found a decrease in both butyrate and certain bacteria that produce butyrate. Butyrate is a factor related to the protection of the intestinal barrier and appears to play a role in the regulation of the immune system. Both papers are published in the journal Cell Host and Microbe.