Eating more ultra-processed foods is linked to a higher risk of health problems, according to an umbrella review of 45 previous meta-analyses, involving almost 10 million people in total. The research, published in The BMJ, finds direct associations between exposure to ultra-processed foods and 32 health parameters. The strongest evidence links this exposure to cardiometabolic health problems, mental disorders and overall mortality.

Sexual harassment on public transport affects the health and well-being of women around the world, according to a study by the University of Valencia. These events cause them to change their behaviour - for example, they travel accompanied, avoid certain places and stations or certain times of the day - as explained by the research, which analyses almost 30 previous studies carried out on several continents. The authors, whose study is published in PLoS ONE, highlight the contrast between "high government awareness of the problem and the paucity of measures to improve women's safety on transport". In addition, they propose including women in transport decision-making.

Epigenetic editing is a technique that aims to alter gene expression without the need to modify the DNA sequence, as gene editing techniques do. In this way, Italian researchers have succeeded in silencing the PCSK9 gene in mice, thereby reducing cholesterol levels by half for at least a year. According to the authors, and assuming further evaluation is needed, their platform "could lay the foundations for the development of this type of therapy". The results are published in the journal Nature.

Sperm from older fathers are more likely to pass on new mutations that would cause congenital disorders to their babies, while other mutations are independent of paternal age, says a study published in Genome Biology and Evolution. The team analysed the frequency of ten FGFR3 gene variants in semen samples from anonymous donors aged 23-59 years in Austria. Two pathogenic mutations of this gene do occur more frequently in older fathers: those associated with achondroplasia and with thanatophoric dysplasia, a rare and very fatal disease. Other mutations have no correlation with paternal age and may occur in the testes before sexual maturation, according to the study.

A team of researchers at the Centre for Genomic Regulation in Barcelona (CRG) has found that a region of the genome is less active in model mice and people with Down's syndrome. This region is found in the so-called dark genome and does not code for a protein. According to the authors of the study, this "leads to reduced neurogenesis and impaired plasticity, which play a direct role in learning and memory". The results are published in the journal Molecular Psychiatry.

The President of the Government, Pedro Sánchez, announced last night at the welcome dinner of the GSMA Mobile World Congress (MWC) Barcelona 2024, the construction of a foundational model of artificial intelligence language, trained in Spanish and co-official languages, in open and transparent code, and with the intention of incorporating Latin American countries. For its development, the Government will work with the Barcelona Supercomputing Center and the Spanish Supercomputing Network, together with the Spanish Academy of Language and the Association of Spanish Language Academies.

The European Medicines Agency (EMA) has recommended granting marketing authorisation in the European Union for a new therapy for the treatment of adult patients with amyotrophic lateral sclerosis (ALS), a rare and frequently fatal disease that causes muscle weakness and leads to paralysis. Qalsody (tofersen) is indicated for the treatment of adults with ALS who have a mutation in the SOD1 gene. There is currently only one treatment for ALS authorised in the EU (riluzole).

US research has analysed data from more than 300,000 people and found that both men with fertility problems and their family members have an increased risk of developing various types of cancer and at an earlier age. The results are published in the journal Human Reproduction.

Children born in October are more likely to be vaccinated against flu during that month and less likely to be diagnosed with the disease than those born in other months, according to a study published in BMJ. The research involved more than 800,000 US children aged two to five years who were vaccinated against the flu between 1 August and 31 January in the period from 2011 to 2018. The results suggest that the month of birth is related to both the timing of flu vaccination and the likelihood of flu diagnosis, and that October is the best month for flu vaccination.

Access to safe public spaces to meet, employment, education and public health are some of the main measures recommended to make cities more friendly to the mental health of young people and adolescents. The analysis, based on surveys of 518 people in several countries, is published in the journal Nature and is intended to serve as a guide for urban planning policies that reduce inequalities and take into account the needs of young people.