A phase 2 clinical trial has tested a type of immunotherapy based on oncolytic viruses in combination with chemotherapy for the treatment of triple-negative breast tumours. The results are published in the journal Nature Medicine.

People who have a parent, sibling, or step-sibling with major depression have a higher risk of major depression themselves, according to research based on data from 2.9 million people in Denmark. This risk increases with the number of affected relatives and when exposure to depression occurs in childhood and adolescence, but does not vary by sex or kinship, says the study published in JAMA Psychiatry.

Two studies have found changes in the microbiome of patients affected by chronic fatigue syndrome. In particular, they have found a decrease in both butyrate and certain bacteria that produce butyrate. Butyrate is a factor related to the protection of the intestinal barrier and appears to play a role in the regulation of the immune system. Both papers are published in the journal Cell Host and Microbe.

A series on breastfeeding published today in The Lancet highlights the economic and political power of formula companies, examines their marketing practices and the impact this has on the health of mothers and children.

As rising temperatures melt glaciers, meltwater can accumulate and form lakes nearby. These bodies of water represent a natural hazard because of the floods they cause if they overflow. Researchers have estimated that 15 million people are at risk from these floods, and more than half of them live in just four countries: India, Pakistan, Peru and China. The research is published in Nature Communications.

Early this morning, an earthquake with a magnitude of 7.8 struck southeastern Turkey and northern Syria. The authorities have reported thousands of deaths and extensive material damage. A second earthquake has occurred further north than the previous one.

Researchers have analysed the efficacy of the meningococcal serogroup B vaccine (4CMenB, Bexsero) in more than 1,500 children under five years of age in Spain. The research, published in the New England Journal of Medicine, shows that full vaccination was effective in preventing invasive meningococcal disease of both serogroup B and other serogroups in this child population. The vaccine, which had been sold privately in Spain since 2015, had already been included by several autonomous communities in their vaccination schedules. Last December, the Interterritorial Council of the National Health System (CISNS) approved its inclusion in the vaccination schedule for the whole of Spain.

Beta-blockers (β-blockers) are drugs to treat heart conditions that are also used for anxiety. According to research published in PLOS Medicine, periods of treatment with these drugs are associated with a lower risk of being charged by the police with a violent crime - a 13% lower risk than periods without treatment. The research, which included nearly 1.5 million people in Sweden between 2006 and 2013, does not support the use of these drugs to treat anxiety.

A meta-analysis of 42 studies from 15 countries, including Spain, concludes that the covid-19 pandemic caused learning delays in school-aged children and a loss of knowledge equivalent to 35% of the learning of a school year. The research, published in Nature Human Behaviour, highlights that these effects persisted over time.

The World Health Organisation's (WHO) International Health Regulations Committee on Emergencies has decided to maintain the covid-19 pandemic as a Public Health Emergency of International Concern (PHEIC) after meeting last Friday.